Figure 2
From: Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome
Epigenetic signature of T21. a) Heatmap of beta values of probes that were significantly different between DS and control participants with a difference between the means of the groups >10%, 3300 probes total. Yellow indicates higher methylation, and blue indicates lower methylation. DS participants are shown in blue, controls in red. b) Scatterplot showing relationship of ∆beta (mean difference in beta value between DS and control participants, y-axis) and distance to transcriptional start site (TSS, x-axis). Probes in red are significantly differently methylated between DS and control as in a. c) Breakdown of CpG island type in entire array (left column) and significantly different probes shown in a (right column). d) Heatmap of beta values of probes from a that also overlap with regions of differential methylation identified using the “Bump Hunter” method, 495 total. e) Scatterplot showing relationship of ∆beta (mean difference in beta value between DS and control participants, y-axis) and distance to transcriptional start site (TSS, x-axis). Probes in red are significantly differently methylated between DS and control as in d. f) Breakdown of CpG island type in entire array (left column) and significantly different probes shown in d (right column).