DNA methylation sites correlated with cognitive impairment in DS participants. a) Normal Q-Q plot of Spearman rho correlation coefficients for all probes. S-shape indicates small tails on the distribution of coefficients. Black points are non-significant probes, red points are probes which survive Benjamini-Hochberg correction for correlation between DNA methylation and BPT in DS participants. b-e) BPT scores (x-axis) plotted against beta values (y-axis) for five probes found to be significantly correlated with BPT in DS participants and significantly different between DS and controls. Blue points indicate DS participants and red points indicate controls. b) RND1 c) BICC1 d) KIAA1644 and e) Two probes in TSC2.