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Table 1 Phenotypic characteristics and heritability estimates of the MetS cohort

From: Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a northern european family population

  Trait Mean ± STD (Male) Mean ± STD (Female) Heritability ± SE
Body Composition Weight, kg 97.73 ± 26.30 90.28 ± 25.92 0.40±0.10
Height, cm 176.34 ± 6.97 163.46 ± 6.95 0.69±0.07
BMI, kg/m2 31.45 ± 8.40 33.95 ± 10.19 0.43±0.09
Waist circumference (WC), cm 102.12 ± 18.34 97.77 ± 20.16 0.33±0.09
Hip circumference (HC), cm 109.44 ± 16.52 117.95 ± 20.40 0.43±0.10
Waist to Hip ratio (WHR) 0.93 ± 0.08 0.83 ± 0.09 0.23±0.09
Total Fat Mass (Fatkg), kg 28.49 ± 13.81 38.01 ± 14.68 0.41±0.11
Total Fat Mass (Fatpct),% 29.78 ± 9.02 43.94 ± 7.79 0.39±0.10
Total Lean Mass (Leankg), kg 62.53 ± 8.23 45.81 ± 8.44 0.55±0.09
Total Lean Mass (Leanpct), % 74.29 ± 39.60 57.74 ± 28.07 0.38±0.10
Subcutaneous Fat (SubQF), g 72.61 ± 44.52 93.54 ± 48.94 0.57±0.10
Visceral Fat (VF), g 57.32 ± 30.54 42.86 ± 29.17 0.34±0.10
Total Abdominal Fat (TAF), g 128.96 ± 66.28 136.82 ± 69.39 0.54±0.10
Respiratory Quotient (RQ) 0.83 ± 0.09 0.83 ± 0.08 0.30±0.09
Resting Energy Expenditure (REE), kcal/24 hrs 1931.18 ± 327.99 1620.70 ± 292.96 0.34±0.10
REE/weight, kcal/24hrs/kg 20.17 ± 3.64 18.62 ± 3.21 0.37±0.11
REE/Lean mass (REE/lean), kcal/24hrs/kg 30.37 ± 3.83 35.18 ± 4.28 0.36±0.11
Glucose and Insulin Responsiveness Fasting Glucose (FG), mg/dl 88.53 ± 30.35 87.14 ± 30.83 0.51±0.09
Fasting Insulin (FI),μU/ml 15.96 ± 12.90 19.24 ± 24.53 0.38±0.08
Insulin/glucose (IGR) 0.27 ± 0.76 0.29 ± 0.93 0.35±0.08
Homeostasis model assessment (HOMA) 3.52 ± 3.04 4.63 ± 9.92 0.38±0.08
Insulin Sensitivity (SI), (× 10-4/min/μU/ml) 3.32 ± 2.94 2.86 ± 2.79 0.20±0.10
Glucose Effectiveness (SG), min-1 0.02 ± 0.01 0.02 ± 0.02 0.12±0.10
Acute Insulin Response to glucose (AIRG), μU/ml × 10min 537.09 ± 477.19 416.81 ± 338.89 0.12±0.08
Disposition Index (DI), AUC (Insulin0-10 min) × SI 1367.12 ± 1188.95 1054.62 ± 996.43 0.25±0.09
Lipid Homeostasis Triglycerides (TG), mg/dl 135.40 ± 208.06 106.45 ± 64.89 0.52±0.11
Total cholesterol (TC), mg/dl 193.08 ± 45.75 189.06 ± 40.03 0.29±0.08
LDL-cholesterol (LDL-c), mg/dl 131.44 ± 40.55 126.95 ± 36.61 0.33±0.09
Calculated LDL-C (cal. LDL-c), mg/dl 134.83 ± 55.40 126.53 ± 38.97 0.45±0.10
HDL-cholesterol (HDL-c), mg/dl 38.24 ± 12.05 43.65 ± 18.63 0.69±0.08
HMED, nm 8.83 ± 0.31 9.19 ± 0.50 0.40±0.10
LMEDn, nm 27.03 ± 0.70 27.26 ± 0.97 0.46±0.11
LDL_PPD, nm 27.17 ± 0.95 27.99 ± 1.30 0.61±0.10
BMED, nm 27.67 ± 1.09 28.07 ± 1.28 0.42±0.10
Cardiovascular Performance Systolic Blood Pressure (sBP), mmHg 128.69 ± 15.34 124.90 ± 19.07 0.22±0.09
Diastolic Blood Pressure (dBP), mmHg 78.97 ± 12.18 75.68 ± 10.74 0.22±0.10
Pulse, beats/min 68.59 ± 9.85 72.93 ± 21.31 0.15±0.08
Adipokines and Cytokines Adiponectin, ng/ml 6.66 ± 3.06 9.47 ± 4.77 0.60±0.09
Leptin, ng/ml 11.07 ± 10.90 25.34 ± 15.19 0.41±0.09
TNF-alpha, pg/ml 4.26 ± 2.67 3.74 ± 2.53 0.38±0.09
Interleukin-1 beta (IL-1β) 0.40 ± 0.95 0.46 ± 0.96 0.23±0.10
  Interleukin-6 (IL-6) 3.75 ± 8.53 5.42 ± 9.44 0.20±0.09
  1. The mean +/− standard deviation is shown for each of the 42 MetS phenotypes. Heritability of MetS phenotypes estimated in these 40 extended families (n=517) is shown with standard errors (SE). For nomenclature of the 42 phenotypes, refer to Materials and Methods.