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Table 2 Heritability and correlations with age and sex of methylation status near FABP3 start codon

From: Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a northern european family population

CpG site

Heritability ±SE

Pheritability

β±SEage

Page

Variance explained age

β±SEsex

Psex

Variance explained sex

FABP3_1

0.21 ± 0.07

2.85E-05

1.70E-04 ± 1.00E-04

1.03E-01

2.99E-03

1.90E-03 ± 3.50E-03

5.87E-01

2.19E-04

FABP3_2

0.05 ± 0.07

1.89E-01

1.60E-04 ± 4.90E-05

1.64E-03

1.03E-02

−7.30E-04 ± 1.60E-03

6.59E-01

1.98E-04

FABP3_3

0.09 ± 0.08

1.11E-01

1.50E-04 ± 6.20E-05

1.32E-02

1.41E-02

4.60E-03 ± 2.00E-03

2.34E-02

5.55E-03

FABP3_4

0.18 ± 0.08

4.39E-03

4.00E-05 ± 5.00E-05

4.11E-01

1.27E-03

2.70E-03 ± 1.60E-03

8.93E-02

3.10E-03

FABP3_5

0.15 ± 0.07

7.38E-03

1.10E-04 ± 3.20E-05

7.44E-04

1.41E-02

5.40E-04 ± 1.00E-03

6.06E-01

7.51E-05

FABP3_6/7

0.17 ± 0.08

5.15E-03

1.20E-04 ± 3.20E-05

1.09E-04

1.52E-02

2.50E-04 ± 1.10E-03

8.11E-01

2.61E-05

FABP3_8

0.17 ± 0.08

3.23E-03

−2.00E-05 ± 9.80E-05

8.35E-01

3.09E-04

6.20E-03 ± 3.20E-03

5.23E-02

3.44E-03

FABP3_9

0.48± 0.08

4.53E-17

2.90E-04 ± 7.10E-05

3.95E-05

2.09E-02

−7.60E-04 ± 2.40E-03

7.48E-01

1.31E-04

FABP3_10/11/12

0.19 ± 0.09

4.40E-03

2.80E-04 ± 6.80E-05

5.77E-05

2.05E-02

6.00E-03 ± 2.20E-03

6.55E-03

7.31E-03

FABP3_13

0.46 ± 0.10

1.06E-09

2.20E-04 ± 1.10E-04

3.75E-02

8.40E-03

3.90E-03 ± 3.50E-03

2.66E-01

1.58E-03

FABP3_14

0.48 ± 0.10

2.41E-09

2.80E-04 ± 1.30E-04

3.51E-02

7.52E-03

1.30E-02 ± 4.40E-03

2.50E-03

1.11E-02

FABP3_15

0.15 ± 0.07

3.92E-03

−2.80E-04 ± 1.40E-04

4.77E-02

4.15E-03

4.50E-03 ± 4.60E-03

3.34E-01

9.95E-04

FABP3_16

0.32 ± 0.10

1.90E-05

2.30E-04 ± 8.70E-05

8.20E-03

1.04E-02

6.30E-03 ± 2.80E-03

2.72E-02

5.63E-03

FABP3_17/18

0.03 ± 0.06

2.80E-01

1.30E-04 ± 1.40E-04

3.49E-01

9.21E-04

7.60E-03 ± 4.70E-03

1.03E-01

2.78E-03

FABP3_19

0.26 ± 0.09

5.76E-05

−3.30E-04 ± 1.10E-04

2.97E-03

5.46E-03

1.30E-02 ± 3.60E-03

3.88E-04

1.16E-02

FABP3_20

0.41 ± 0.09

4.52E-09

1.00E-05 ± 9.30E-05

8.79E-01

2.61E-05

8.10E-03 ± 3.10E-03

8.91E-03

3.88E-03

FABP3_21/22

0.14± 0.08

2.15E-02

−7.00E-05 ± 1.60E-04

6.34E-01

5.56E-04

−5.50E-03 ± 5.40E-03

3.06E-01

2.50E-03

FABP3_AVG

0.22 ± 0.07

9.35E-06

9.30E-04 ± 6.10E-04

1.24E-01

5.00E-03

6.00E-02 ± 2.00E-02

2.23E-03

5.99E-03

  1. Heritability (±SE) estimates are shown for the 17 individual CpG units and their average. Significance p-values for heritability estimates are shown. Association β (±SE) values, their associated significance p-values, and the portion of total variance in methylation explained by age and sex are also shown.
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BMC Medical Genomics

ISSN: 1755-8794

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