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Table 3 Enriched pathways of differentially expressed genes

From: Integrated lipidomics and transcriptomic analysis of peripheral blood reveals significantly enriched pathways in type 2 diabetes mellitus

Rank KEGG Path ID KEGG pathway name Top 5 loadings gene
1 path:hsa00670 One carbon pool by folate "MTHFD2L" "ALDH1L1" "MTFMT" "ALDH1L2" "MTR"
2 path:hsa00590 Arachidonic acid metabolism "PTGS2""GPX7" "PLB1" "CYP4A11""GPX2"
3 path:hsa04910 Insulin signaling pathway "FLOT2" "PRKAB2""MAPK8" "PPP1R3B" "PIK3CB"
4 path:hsa05110 Vibrio cholerae infection "TJP2" "ATP6V1C1" "ADCY9""ARF1" "ATP6V1H"
5 path:hsa04020 Calcium signaling pathway "HTR4" "TRPC1""ADCY8""CHRM5""GRIN2A"
6 path:hsa00520 Amino sugar and nucleotide sugar metabolism "CHI3L1" "HK2""NPL""HEXA" "UAP1L1"
7 path:hsa04062 Chemokine signaling pathway "CXCL5""CXCL10" "PF4V1""CCL8" "CXCL11"
8 path:hsa00640 Propanoate metabolism "MLYCD" "ALDH2" "ACSS1" "PCCB""ALDH3A2"
9 path:hsa00500 Starch and sucrose metabolism "UGT2B17" "UGT2B15" "MGAM""HK1" "AMY2B"
10 path:hsa00240 Pyrimidine metabolism "DPYD""ENTPD1""TXNRD1""TK2" "TYMP"
  1. Top Ten Enriched Pathways of most Factor Loading Genes. KEGG Path ID represents for KEGG pathway ID[19], which is ranked by pvalues of enrichment analysis. Pathways in gray lines have at least one bold marked gene, which is selected as a feature in gene based classifier. And the pathways in gray lines are the pathways that directly linked with diabetes r by the marked genes.