Integrated lipidomics and transcriptomic analysis of peripheral blood reveals significantly enriched pathways in type 2 diabetes mellitus

Table 3 Enriched pathways of differentially expressed genes

Rank	KEGG Path ID	KEGG pathway name	Top 5 loadings gene
1	path:hsa00670	One carbon pool by folate	"MTHFD2L" "ALDH1L1" "MTFMT" "ALDH1L2" "MTR"
2	path:hsa00590	Arachidonic acid metabolism	"PTGS2""GPX7" "PLB1" "CYP4A11""GPX2"
3	path:hsa04910	Insulin signaling pathway	"FLOT2" "PRKAB2""MAPK8" "PPP1R3B" "PIK3CB"
4	path:hsa05110	Vibrio cholerae infection	"TJP2" "ATP6V1C1" "ADCY9""ARF1" "ATP6V1H"
5	path:hsa04020	Calcium signaling pathway	"HTR4" "TRPC1""ADCY8""CHRM5""GRIN2A"
6	path:hsa00520	Amino sugar and nucleotide sugar metabolism	"CHI3L1" "HK2""NPL""HEXA" "UAP1L1"
7	path:hsa04062	Chemokine signaling pathway	"CXCL5""CXCL10" "PF4V1""CCL8" "CXCL11"
8	path:hsa00640	Propanoate metabolism	"MLYCD" "ALDH2" "ACSS1" "PCCB""ALDH3A2"
9	path:hsa00500	Starch and sucrose metabolism	"UGT2B17" "UGT2B15" "MGAM""HK1" "AMY2B"
10	path:hsa00240	Pyrimidine metabolism	"DPYD""ENTPD1""TXNRD1""TK2" "TYMP"

Top Ten Enriched Pathways of most Factor Loading Genes. KEGG Path ID represents for KEGG pathway ID[19], which is ranked by pvalues of enrichment analysis. Pathways in gray lines have at least one bold marked gene, which is selected as a feature in gene based classifier. And the pathways in gray lines are the pathways that directly linked with diabetes r by the marked genes.