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Table 1 The 28 significant pathways analysed using ClueGO.
| Significant Pathways | Specific To cluster | Adjust P-Value | Total number | Gene source | ||
|---|---|---|---|---|---|---|
| unique SCZ gene count | unique T2D gene count | Common gene count | ||||
| Adipocytokine signaling pathway | T2D | 3.91E-09 | 18 | 4 | 12 | 2 |
| Neuroactive ligand-receptor interaction | SCZ | 4.01E-09 | 35 | 26 | 9 | 0 |
| Maturity onset diabetes of the young | T2D | 1.94E-08 | 11 | 0 | 11 | 0 |
| Type II diabetes mellitus | T2D | 1.98E-08 | 14 | 1 | 12 | 1 |
| PPAR signaling pathway | T2D | 9.33E-07 | 15 | 2 | 13 | 0 |
| Calcium signaling pathway | SCZ | 5.03E-06 | 23 | 18 | 5 | 0 |
| Visceral Fat Deposits and the Metabolic Syndrome | T2D | 6.57E-05 | 5 | 0 | 4 | 1 |
| Type I diabetes mellitus | SCZ | 7.12E-05 | 10 | 8 | 1 | 1 |
| Corticosteroids and cardioprotection | BOTH | 8.96E-05 | 6 | 3 | 2 | 1 |
| Low-density lipoprotein (LDL) pathway during atherogenesis | T2D | 3.28E-04 | 4 | 0 | 4 | 0 |
| Insulin signaling pathway | T2D | 9.20E-04 | 16 | 1 | 15 | 0 |
| Graft-versus-host disease | SCZ | 0.001587097 | 8 | 6 | 1 | 1 |
| IL-10 Anti-inflammatory Signaling Pathway | BOTH | 0.001671861 | 4 | 1 | 1 | 2 |
| Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression | T2D | 0.001780493 | 3 | 0 | 3 | 0 |
| Actions of Nitric Oxide in the Heart | BOTH | 0.002369651 | 5 | 2 | 3 | 0 |
| Erythropoietin mediated neuroprotection through NF-kB | BOTH | 0.003426765 | 4 | 2 | 1 | 1 |
| Allograft rejection | SCZ | 0.003509 | 7 | 5 | 0 | 2 |
| g-Secretase mediated ErbB4 Signaling Pathway | SCZ | 0.005740212 | 3 | 3 | 0 | 0 |
| Msp/Ron Receptor Signaling Pathway | BOTH | 0.005740212 | 3 | 1 | 1 | 1 |
| Autoimmune thyroid disease | SCZ | 0.020029548 | 7 | 6 | 0 | 1 |
| Alzheimer's disease | BOTH | 0.020096651 | 5 | 1 | 2 | 2 |
| Free Radical Induced Apoptosis | SCZ | 0.020961818 | 3 | 2 | 0 | 1 |
| Role of PPAR-gamma Coactivators in Obesity and Thermogenesis | T2D | 0.020961818 | 3 | 0 | 3 | 0 |
| Asthma | SCZ | 0.023911463 | 5 | 3 | 0 | 2 |
| AKT Signaling Pathway | SCZ | 0.024540904 | 4 | 3 | 1 | 0 |
| Hematopoietic cell lineage | BOTH | 0.027660527 | 9 | 4 | 4 | 1 |
| Regulation of PGC-1a | T2D | 0.029865431 | 3 | 1 | 2 | 0 |
| Role of ERBB2 in Signal Transduction and Oncology | T2D | 0.030339933 | 4 | 1 | 3 | 0 |
