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Table 1 The 28 significant pathways analysed using ClueGO.

From: Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis

Significant Pathways Specific To cluster Adjust P-Value Total number Gene source
     unique SCZ gene count unique T2D gene count Common gene count
Adipocytokine signaling pathway T2D 3.91E-09 18 4 12 2
Neuroactive ligand-receptor interaction SCZ 4.01E-09 35 26 9 0
Maturity onset diabetes of the young T2D 1.94E-08 11 0 11 0
Type II diabetes mellitus T2D 1.98E-08 14 1 12 1
PPAR signaling pathway T2D 9.33E-07 15 2 13 0
Calcium signaling pathway SCZ 5.03E-06 23 18 5 0
Visceral Fat Deposits and the Metabolic Syndrome T2D 6.57E-05 5 0 4 1
Type I diabetes mellitus SCZ 7.12E-05 10 8 1 1
Corticosteroids and cardioprotection BOTH 8.96E-05 6 3 2 1
Low-density lipoprotein (LDL) pathway during atherogenesis T2D 3.28E-04 4 0 4 0
Insulin signaling pathway T2D 9.20E-04 16 1 15 0
Graft-versus-host disease SCZ 0.001587097 8 6 1 1
IL-10 Anti-inflammatory Signaling Pathway BOTH 0.001671861 4 1 1 2
Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression T2D 0.001780493 3 0 3 0
Actions of Nitric Oxide in the Heart BOTH 0.002369651 5 2 3 0
Erythropoietin mediated neuroprotection through NF-kB BOTH 0.003426765 4 2 1 1
Allograft rejection SCZ 0.003509 7 5 0 2
g-Secretase mediated ErbB4 Signaling Pathway SCZ 0.005740212 3 3 0 0
Msp/Ron Receptor Signaling Pathway BOTH 0.005740212 3 1 1 1
Autoimmune thyroid disease SCZ 0.020029548 7 6 0 1
Alzheimer's disease BOTH 0.020096651 5 1 2 2
Free Radical Induced Apoptosis SCZ 0.020961818 3 2 0 1
Role of PPAR-gamma Coactivators in Obesity and Thermogenesis T2D 0.020961818 3 0 3 0
Asthma SCZ 0.023911463 5 3 0 2
AKT Signaling Pathway SCZ 0.024540904 4 3 1 0
Hematopoietic cell lineage BOTH 0.027660527 9 4 4 1
Regulation of PGC-1a T2D 0.029865431 3 1 2 0
Role of ERBB2 in Signal Transduction and Oncology T2D 0.030339933 4 1 3 0
  1. SCZ: schizophrenia; T2D: type 2 diabetes mellitus. The p-value is adjusted by Benjamini-Hochberg method.