Figure 1

The overview of the method. Twenty eight subjects were allocated in the microarray study, the MRI and quantitative real-time PCR (QRT-PCR) study, and immunohistochemical study, respectively. In the microarray study, differentially expressed genes (DEGs) of T-CMT were identified (A-B). The discriminant power of the DEGs (C) was examined and the gene ontology enrichment analysis (D) was done. The CMT-related network modules (E) were identified. In the MRI and QRT-PCR study, the pre-operational neck MRI was taken and analyzed (F-G). The expression level of 8 selected DEGs in T-CMT was measured through the QRT-PCR assay (H). The correlation between the expression level of the DEGs and pre-operational MRI findings was examined (I). The expression of the proteins encoded by the DEGs of CMT was examined using immunohistochemical examination for 5 subjects with CMT compared to the normal SCM muscles from the Bio-resource Bank (J-K).