Characteristics of coexpression networks over the course of treatment with letrozole. Coexpression networks are built from gene expression data measured at diagnosis (Pre-treatment), following 10-14 days of letrozole treatment (Mid-treatment), and following 90 days of letrozole treatment (Post-treatment). The largest connected component is the number of nodes within the largest subgraph. Mean path length is a measure of the average distance between all pairs of nodes within the largest connected component of the network. The global clustering coefficient is the probability that neighboring nodes of a given node are connected.