Key genes for modulating information flow play a temporal role as breast tumor coexpression networks are dynamically rewired by letrozole

Table 1 Topological properties

	Number of Nodes	Number of Links	Largest Connected Component	Mean Path Length	Global Clustering Coefficient
Pre-treatment	1044	2262	942	5.16	0.090
Mid-treatment	1044	2462	957	5.12	0.089
Post-treatment	1044	2858	982	4.79	0.103

Characteristics of coexpression networks over the course of treatment with letrozole. Coexpression networks are built from gene expression data measured at diagnosis (Pre-treatment), following 10-14 days of letrozole treatment (Mid-treatment), and following 90 days of letrozole treatment (Post-treatment). The largest connected component is the number of nodes within the largest subgraph. Mean path length is a measure of the average distance between all pairs of nodes within the largest connected component of the network. The global clustering coefficient is the probability that neighboring nodes of a given node are connected.

ISSN: 1755-8794