Table 1 Explanation of the scoring functions evaluated.

Cosine Distance of Term Frequency-Inverse Document Frequency

${\displaystyle \sum _{j\in M}}\left(c_i\left(j\right)d_i\left(j\right)\right)/\left(\sqrt{{\displaystyle \sum _{j\in M}}{\left(c_i\left(j\right)\right)}^2}\sqrt{{\displaystyle \sum _{j\in M}}{\left(d_i\left(j\right)\right)}^2}\right)$

Cosine Distance of p-values

${\displaystyle \sum _{i\in M}}\left(c_p\left(i\right)d_p\left(i\right)\right)/\left(\sqrt{{\displaystyle \sum _{i\in M}}{\left(c_p\left(i\right)\right)}^2}\sqrt{{\displaystyle \sum _{i\in M}}{\left(d_p\left(i\right)\right)}^2}\right)$

Cosine Distance of term fractions

${\displaystyle \sum _{i\in M}}\left(c_f\left(i\right)d_f\left(i\right)\right)/\left(\sqrt{{\displaystyle \sum _{i\in M}}{\left(c_f\left(i\right)\right)}^2}\sqrt{{\displaystyle \sum _{i\in M}}{\left(d_f\left(i\right)\right)}^2}\right)$

Sum of the log of combined p-values

${\displaystyle \sum _{i\in M}}\text{log}\left(c_p\left(i\right)+d_p\left(i\right)-c_p\left(i\right)d_p\left(i\right)\right)$

Sum of the differences of log p values

${\displaystyle \sum _{i\in M}}\left|\text{log}\left(\frac{c_p\left(i\right)}{d_p\left(i\right)}\right)\right|={\displaystyle \sum _{i\in M}}\left|\text{log}\left(c_p\left(i\right)\right)-\text{log}\left(d_p\left(i\right)\right)\right|$

L₂ of log-p of overlapping terms only

$\sqrt{{\displaystyle \sum _{i\in \left(C\cap D\right)}}{\left(\text{log}\left(c_p\left(i\right)\right)-\text{log}\left(d_p\left(i\right)\right)\right)}^2}$

L₂ of term fractions of overlapping terms only

$\sqrt{{\displaystyle \sum _{i\in \left(C\cap D\right)}}{\left(c_f\left(i\right)-d_f\left(i\right)\right)}^2}$

L₂ of log of p-values

$\sqrt{{\displaystyle \sum _{i\in M}}{\left(\text{log}\left(\frac{c_p\left(i\right)}{d_p\left(i\right)}\right)\right)}^2}=\sqrt{{\displaystyle \sum _{i\in M}}{\left(\text{log}\left(c_p\left(i\right)\right)-\text{log}\left(d_p\left(i\right)\right)\right)}^2}$

L₂ of p-values

$\sqrt{{\displaystyle \sum _{i\in M}}{\left(c_p\left(i\right)-d_p\left(i\right)\right)}^2}$

L₂ of term fractions

$\sqrt{{\displaystyle \sum _{i\in M}}{\left(c_f\left(i\right)-d_f\left(i\right)\right)}^2}$

L₂ of term frequency

$\sqrt{{\displaystyle \sum _{i\in M}}{\left(c\left(i\right)-d\left(i\right)\right)}^2}$

Term Coverage

$\left|C\cup D\right|$

Term Overlap

$\left|C\cap D\right|$

Number of Drug MeSH Terms

$\left|C\right|$

Number of Disease MeSH Terms

$\left|D\right|$