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Table 3 Comparison of top drug candidates for gout.

From: Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity

 

Corrected Predictions

Original Predictions

Rank

Drug

Score

Articles

Drug

Score

Articles

1

Kebuzone

0.14

2

Antibodies, Monoclonal

3.66E+08

4

2

Alminoprofen

0.17

1

Glucose

3.64E+08

5

3

Benziodarone

0.24

3

Insulin

3.24E+08

5

4

Proquazone

0.26

1

Norepinephrine

3.14E+08

1

5

Isoxicam

0.35

1

Tetradecanoylphorbol Acetate

3.02E+08

1

6

Glucametacin

0.48

 

Immunoglobulin G

2.98E+08

11

7

proglumetacin

0.52

2

Nitric Oxide

2.97E+08

5

8

imidazole-2-hydroxybenzoate

0.52

 

Interferon-gamma

2.88E+08

1

9

Prenazone

0.57

1

Serotonin

2.69E+08

4

10

diclofenac hydroxyethylpyrrolidine

0.59

 

Antibodies

2.62E+08

5

  1. We compare the top 10 drug candidates after applying our described correction against the top 10 candidates before correction. Articles lists the number of MEDLINE articles in which the MeSH term "Gout" and the drug co-occur.