Table 2 Comparison of FAIME-prioritized mechanisms against controls (standard bioinformatics)
From: Curation-free biomodules mechanisms in prostate cancer predict recurrent disease
Gene Ontology ( n = union of {4877 up-} ∪ {4877 down-} regulated) | Cancer Module ( n = {454 up-} ∪ {454 down-} regulated) | Diff. Expressed Genes | GO Enrichment from Diff. Expressed Genes (# terms; n = 4877) | ||
|---|---|---|---|---|---|
Human Prostate Cancer Dataset | FDR | FAIME-Derived Mechanisms | Controls: Standard Bioinformatics Approaches* | ||
Yu | 0.01 | 28% (2703) | 25% (230) | 2.3% (208/8799) | 0.3% (14) |
0.05 | 32% (3137) | 31% (282) | 3.3% (293/8799) | 0.4% (21) | |
Wallace | 0.01 | 5% (441) | 4% (36) | 2.5% (326/12680) | 0.1% (4) |
0.05 | 13% (1226) | 9% (83) | 4.5% (574/12680) | 0.2% (10) | |
Taylor | 0.01 | 17% (1672) | 12% (109) | 0.7% (202/26448) | 0.1% (6) |
0.05 | 25% (2395) | 19% (168) | 1.0% (266/26448) | 0.2% (9) | |