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Table 3 Sensitivities and Specificities (Multivariable Models)

From: A comparison of statistical methods for the detection of hepatocellular carcinoma based on serum biomarkers and clinical variables

Method (Model)1 Sensitivity (95% CI) Sensitivity (LOOCV)3 Specificity (95% CI)4 Specificity (LOOCV)
stepPLR (λ = 0.1) (male only, with age) 89.92(85.69-95.80) 89.08 83.82(73.53-91.18) 82.35
stepPLR (λ = 1) (male only, with age) 90.76(86.55-95.81) 89.92 86.76(77.94-94.12) 82.35
stepPLR (λ = 10) (male only, with age) 90.75(86.56-95.81) 88.24 88.24(75.00-92.65) 83.82
stepPLR (λ = 0.1) (male only, without age) 84.87(79.83-90.76) 84.03 80.88(70.59-89.71) 79.41
stepPLR (λ = 1) (male only, without age) 84.82(78.15-90.76) 83.19 83.82(75.00-92.65) 77.94
stepPLR (λ = 10) (male only, without age) 84.03(78.15-91.60) 84.03 85.29(76.47-92.65) 83.82
stepPLR (λ = 0.1) (gender, with age) 89.94(84.91-94.39) 89.94 86.67(80.00-92.38) 83.81
stepPLR (λ = 1) (gender, with age) 90.57(86.16-94.94) 89.31 86.67(80.00-93.33) 86.66
stepPLR (λ = 10) (gender, with age) 89.31(84.28-93.71) 88.68 88.57(81.90-94.29) 88.58
stepPLR (λ = 0.1) (gender, without age) 86.16(86.50-91.19) 84.91 84.76(77.14-91.43) 84.76
stepPLR (λ = 1) (gender, without age) 85.53(79.87-90.57) 84.90 85.71(80.00-93.33) 84.76
stepPLR (λ = 10) (gender, without age) 84.27(79.87-90.57) 81.76 86.66(80.00-92.38) 86.66
mob(AAT|~.) with age, male only) 90.43(79.36-95.63) 86.96 81.82(73.45-88.33) 77.27
mob(GP73|~.) with age, male only) 88.69(77.51-94.61) 86.08 86.36(78.39-91.83) 80.30
mob(AFP|~.) with age, male only) 93.04(83.20-98.32) 84.34 83.33(75.41-89.75) 75.76
mob(Kin|~.) with age, male only) 91.30(81.26-96.59) 86.96 78.79(67.71-83.92) 84.85
mob(AAT|~.) without age, male only) 88.23(82.35-93.28) 78.15 77.94(67.65-86.76) 72.06
mob(GP73|~.) without age, male only) 85.71(79.83-92.44) 81.51 70.59(60.29-80.88) 67.64
mob(AFP|~.) without age, male only) 86.55(80.67-92.44) 79.83 66.17(54.41-76.47) 60.29
mob(Kin|~.) without age, male only) 92.43(87.39-96.64) 90.75 80.88(70.59-89.71) 75.00
mob(AAT|~.) with age, gender) 89.33(84.28-93.71) 86.16 85.71(79.05-92.38) 77.14
mob(GP73|~.) with age, gender) 94.97(91.82-98.11) 92.45 86.68(80.00-92.38) 80.00
mob(AFP|~.) with age, gender) 91.19(86.75-94.97) 88.05 83.81(76.19-90.48) 76.19
mob(Kin|~.) with age, gender) 94.39(90.54-97.48) 89.30 80.95(73.33-80.95) 74.28
mob(AAT|~.) without age, gender) 88.67(84.28-93.71) 87.42 81.90(74.29-88.57) 80.00
mob(GP73|~.) without age, gender) 83.64(77.36-89.31) 82.39 89.52(83.81-95.24) 84.76
mob(AFP|~.) without age, gender) 88.05(83.65-93.08) 87.42 80.95(73.33-88.65) 76.19
mob(Kin|~.) without age, gender) 91.82(88.05-96.45) 89.93 81.90(75.24-88.60) 77.14
  1. 1. Method utilized for analysis, stepPLR stepwise penalized logistic regression with or without age and/or gender, mob model-based CART, classification and regression trees developed with or without age and/or gender; 2) optimal sensitivity and 95% Confidence interval; 3) Optimal sensitivity following leave one out cross validation; 4) Optimal specificity; 5) Optimal specificity following leave one out cross validation.