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Table 3 Methylation levels of EPs according to tissue type

From: Disease specific characteristics of fetal epigenetic markers for non-invasive prenatal testing of trisomy 21

EP marker

Probe position

Placenta (Log2)

Normal blood (Log2)

Pvalue

(Start-Stop)

Trisomy 21

Normal

Pregnant

Non-pregnant

EP1

40357972-40358018

0.954 ± 1.087

2.495 ± 0.662d,e

0.000 ± 0.000

0.037 ± 0.037

0.006

40358060-40358114

0.501 ± 0.678

1.663 ± 0.533d,e

0.000 ± 0.000

0.000 ± 0.000

0.006

40358069-40358121

0.513 ± 0.581

1.496 ± 0.468d,e

0.000 ± 0.000

0.000 ± 0.000

0.005

40358132-40358191

0.172 ± 0.173a

0.932 ± 0.282d,e

0.000 ± 0.000

0.000 ± 0.000

0.000

EP2

45336733-45336780

0.756 ± 1.309

1.801 ± 1.081

0.000 ± 0.000

0.218 ± 0.218

0.168

45336822-45336870

0.766 ± 1.327

2.247 ± 1.320

0.128 ± 0.221

0.671 ± 0.131

0.143

45336828-45336876

0.727 ± 1.259

2.151 ± 1.257

0.145 ± 0.252

0.892 ± 0.106

0.151

EP3

45336822-45336870

0.766 ± 1.327

2.247 ± 1.320

0.263 ± 0.263

0.000 ± 0.000

0.123

45336828-45336876

0.727 ± 1.259

2.151 ± 1.257

0.395 ± 0.421

0.000 ± 0.000

0.145

EP4

34398855-34398913

1.650 ± 1.060 b

0.833 ± 0.547

0.000 ± 0.000

0.000 ± 0.000

0.045

34398899-34398948

2.423 ± 1.677 b

1.681 ± 1.018

0.000 ± 0.000

0.000 ± 0.000

0.063

EP5

43316483-43316539

0.775 ± 0.930

2.116 ± 0.842

0.297 ± 0.515

0.685 ± 0.428

0.072

43316494-43316553

0.786 ± 0.972

2.135 ± 0.914

0.207 ± 0.358

0.470 ± 0.392

0.057

43316641-43316700

0.538 ± 0.683

0.979 ± 1.097

0.446 ± 0.509

0.871 ± 0.029

0.814

EP6

43482611-43482655

1.159 ± 1.335

2.887 ± 1.844

0.000 ± 0.000

0.000 ± 0.000

0.070

43482725-43482778

1.624 ± 0.792b,c

2.405 ± 0.651d,e

0.000 ± 0.000

0.000 ± 0.000

0.001

EP7

43484105-43484160

1.505 ± 0.922b,c

1.695 ± 0.366d,e

0.000 ± 0.000

0.000 ± 0.000

0.001

43484227-43484272

0.430 ± 0.656

1.384 ± 0.964d

0.000 ± 0.000

0.000 ± 0.000

0.092

EP8

23481701-23481760

0.215 ± 0.372

0.000 ± 0.000

0.000 ± 0.000

0.000 ± 0.000

0.525

EP9

30214808-30214863

0.000 ± 0.000

0.036 ± 0.062

0.000 ± 0.000

0.167 ± 0.167

0.165

EP10

33346983-33347035

1.157 ± 0.930

1.937 ± 0.338d,e

0.000 ± 0.000

0.000 ± 0.000

0.005

33346985-33347037

1.170 ± 1.065

1.951 ± 0.301d,e

0.000 ± 0.000

0.000 ± 0.000

0.010

EP11

45254824-45254879

0.872 ± 0.896

2.002 ± 0.406

0.511 ± 0.642

1.212 ± 0.173

0.088

EP12

38919376-38919423

0.639 ± 1.106

1.762 ± 0.963

0.590 ± 0.700

1.393 ± 0.050

0.361

38919458-38919517

0.814 ± 1.249

1.911 ± 0.983

0.471 ± 0.651

1.412 ± 0.073

0.317

38919529-38919577

0.812 ± 0.948

1.556 ± 0.651

0.329 ± 0.570

1.122 ± 0.165

0.256

  1. Data are presented as mean±standard deviation. Levels were compared using robust one-way analysis of variance (ANOVA), the post hoc Tamhane’s T2 test for multiple comparisons. In post hoc analysis, statistical significance (P < 0.05) is presented as follows: aTrisomy 21 placenta versus normal placenta; bTrisomy 21 placenta versus pregnant women blood; cTrisomy 21 placenta versus non pregnant women blood; dNormal placenta versus pregnant women blood; eNormal placenta versus non pregnant women blood.