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Table 3 Methylation levels of EPs according to tissue type

From: Disease specific characteristics of fetal epigenetic markers for non-invasive prenatal testing of trisomy 21

EP marker Probe position Placenta (Log2) Normal blood (Log2) Pvalue
(Start-Stop) Trisomy 21 Normal Pregnant Non-pregnant
EP1 40357972-40358018 0.954 ± 1.087 2.495 ± 0.662d,e 0.000 ± 0.000 0.037 ± 0.037 0.006
40358060-40358114 0.501 ± 0.678 1.663 ± 0.533d,e 0.000 ± 0.000 0.000 ± 0.000 0.006
40358069-40358121 0.513 ± 0.581 1.496 ± 0.468d,e 0.000 ± 0.000 0.000 ± 0.000 0.005
40358132-40358191 0.172 ± 0.173a 0.932 ± 0.282d,e 0.000 ± 0.000 0.000 ± 0.000 0.000
EP2 45336733-45336780 0.756 ± 1.309 1.801 ± 1.081 0.000 ± 0.000 0.218 ± 0.218 0.168
45336822-45336870 0.766 ± 1.327 2.247 ± 1.320 0.128 ± 0.221 0.671 ± 0.131 0.143
45336828-45336876 0.727 ± 1.259 2.151 ± 1.257 0.145 ± 0.252 0.892 ± 0.106 0.151
EP3 45336822-45336870 0.766 ± 1.327 2.247 ± 1.320 0.263 ± 0.263 0.000 ± 0.000 0.123
45336828-45336876 0.727 ± 1.259 2.151 ± 1.257 0.395 ± 0.421 0.000 ± 0.000 0.145
EP4 34398855-34398913 1.650 ± 1.060 b 0.833 ± 0.547 0.000 ± 0.000 0.000 ± 0.000 0.045
34398899-34398948 2.423 ± 1.677 b 1.681 ± 1.018 0.000 ± 0.000 0.000 ± 0.000 0.063
EP5 43316483-43316539 0.775 ± 0.930 2.116 ± 0.842 0.297 ± 0.515 0.685 ± 0.428 0.072
43316494-43316553 0.786 ± 0.972 2.135 ± 0.914 0.207 ± 0.358 0.470 ± 0.392 0.057
43316641-43316700 0.538 ± 0.683 0.979 ± 1.097 0.446 ± 0.509 0.871 ± 0.029 0.814
EP6 43482611-43482655 1.159 ± 1.335 2.887 ± 1.844 0.000 ± 0.000 0.000 ± 0.000 0.070
43482725-43482778 1.624 ± 0.792b,c 2.405 ± 0.651d,e 0.000 ± 0.000 0.000 ± 0.000 0.001
EP7 43484105-43484160 1.505 ± 0.922b,c 1.695 ± 0.366d,e 0.000 ± 0.000 0.000 ± 0.000 0.001
43484227-43484272 0.430 ± 0.656 1.384 ± 0.964d 0.000 ± 0.000 0.000 ± 0.000 0.092
EP8 23481701-23481760 0.215 ± 0.372 0.000 ± 0.000 0.000 ± 0.000 0.000 ± 0.000 0.525
EP9 30214808-30214863 0.000 ± 0.000 0.036 ± 0.062 0.000 ± 0.000 0.167 ± 0.167 0.165
EP10 33346983-33347035 1.157 ± 0.930 1.937 ± 0.338d,e 0.000 ± 0.000 0.000 ± 0.000 0.005
33346985-33347037 1.170 ± 1.065 1.951 ± 0.301d,e 0.000 ± 0.000 0.000 ± 0.000 0.010
EP11 45254824-45254879 0.872 ± 0.896 2.002 ± 0.406 0.511 ± 0.642 1.212 ± 0.173 0.088
EP12 38919376-38919423 0.639 ± 1.106 1.762 ± 0.963 0.590 ± 0.700 1.393 ± 0.050 0.361
38919458-38919517 0.814 ± 1.249 1.911 ± 0.983 0.471 ± 0.651 1.412 ± 0.073 0.317
38919529-38919577 0.812 ± 0.948 1.556 ± 0.651 0.329 ± 0.570 1.122 ± 0.165 0.256
  1. Data are presented as mean±standard deviation. Levels were compared using robust one-way analysis of variance (ANOVA), the post hoc Tamhane’s T2 test for multiple comparisons. In post hoc analysis, statistical significance (P < 0.05) is presented as follows: aTrisomy 21 placenta versus normal placenta; bTrisomy 21 placenta versus pregnant women blood; cTrisomy 21 placenta versus non pregnant women blood; dNormal placenta versus pregnant women blood; eNormal placenta versus non pregnant women blood.