SNP
|
Chr
|
bp
|
Genes
|
Locus
|
Minor/major allele
|
GWAS(n = 3,451)
|
Validation(n = 8,830)
|
Combined(n = 12,281)
|
---|
MAF
|
Effect size (s.e.m.)
|
P- valuea
|
MAF
|
Effect size (s.e.m.)
|
P
-valuea
|
P-valuea
|
---|
rs11722228
|
4
|
9524839
|
SLC2A9
|
intron
|
T/C
|
0.31
|
0.028 (0.006)
|
3.68 × 10-6
|
0.31
|
0.043 (0.004)
|
4.16 × 10-26
|
8.98 × 10-31
|
rs4148152
|
4
|
89279933
|
ABCG2
|
intron
|
C/T
|
0.35
|
−0.029 (0.006)
|
1.22 × 10-7
|
0.33
|
−0.029 (0.004)
|
4.49 × 10-13
|
2.95 × 10-18
|
rs3114018
|
4
|
89283605
|
ABCG2
|
intron
|
T/G
|
0.38
|
−0.034 (0.006)
|
2.75 × 10-9
|
0.38
|
−0.029 (0.004)
|
1.02 × 10-12
|
4.49 × 10-20
|
rs2231142
|
4
|
89271346
|
ABCG2
|
exon
|
T/G
|
0.29
|
0.046 (0.006)
|
1.19 × 10-14
|
0.31
|
0.045 (0.004)
|
1.01 × 10-25
|
3.34 × 10-42
|
- The NCBI build 36 was used as the reference genome. Chr, chromosome. MAF indicates the minor allele frequency calculated using the data from all the subjects in the analysis. Effect size, represents the effect of a minor allele on the standardized trait (estimated coefficient of the term for the number of the minor alleles).
-
aLinear regression analysis adjusted for age, sex, body mass index (BMI), cigarette smoking, and alcohol drinking.