Table 2 Ethnic differences in major genetic variants associated with serum uric acid levels
| Â | Â | Â | Â | Â | Our study a(Chinese, discovery stage) | Japanese | European ancestry | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | SNP | Chr | Position | Location | MAF (allele) | Effect size | P-value | MAF (allele) | Effect size | P-value | MAF (allele) | Effect size | P-value |
PDZK1 | rs12129861 | 1 | 144437046 | 5′- | 0.20(A) | −0.011 | 0.074 | 0.087(A) | -- | -- | 0.46(A) | −0.062 [20] | 2.68 × 10-9 |
TRIM46 | rs11264341 | 1 | 153418117 | Intron | 0.33(C) | 0.017 | 4.49 × 10-3 | 0.24(C) | 0.074 [25] | 9.5× 10–4 | 0.43(T) | −0.050 [25] | 6.2 × 10–19 |
INHBB | rs17050272 | 2 | 121022910 | N/A | 0.45(A) | 0.008 | 0.174 | 0.49(A) | 0.033 [25] | 4.4× 10–2 | 0.43(A) | 0.035 [25] | 1.6 × 10–10 |
GCKR | rs780094 | 2 | 27594741 | Intron | 0.44(T) | 0.0133 | 0.014 | 0.43(T) | 0.036 [27] | 5.12 × 10-6 | 0.42(T) | 0.050 [20] | 1.40 × 10-9 |
LRP2 | rs2544390 | 2 | 169913092 | Intron | 0.49(C) | −0.001 | 0.73 | 0.49(C) | −0.082 [27] | 3.74 × 10-8 | 0.37(T) | -- | -- |
SFMBT1 | rs6770152 | 3 | 53075254 | N/A | 0.36(T) | −0.010 | 0.071 | 0.46(T) | −0.016 [25] | 0.31 | 0.42(G) | 0.044 [25] | 2.6 × 10–16 |
SLC2A9 | rs11722228 | 4 | 9524839 | Intron | 0.31(T) | 0.028 | 3.68 × 10-6 | 0.45(T) | 0.164 [27] | 7.09 × 10-24 | 0.50(T) | 0.167 [20] | 1.75 × 10-75 |
SLC2A9 | rs16890979 | 4 | 9531265 | Exon | 0.02(T) | −0.024 | 0.285 | 0.01(T) | −0.178 [27] | 3.07 × 10-2 | 0.29(T) | −0.340 [20] | 3.55 × 10-189 |
SLC2A9 | rs734553 | 4 | 9532102 | Intron | 0.02(C) | −0.023 | 0.286 | 0.006(C) | -- | -- | 0.23(C) | 0.315 [20] | 5.22 × 10-201 |
ABCG2 | rs3114018 | 4 | 89283605 | Intron | 0.38(T) | −0.034 | 2.75 × 10-9 | 0.26(A) | -- | -- | 0.48(G) | −0.057 [20] | 2.93 × 10-12 |
ABCG2 | rs2231142 | 4 | 89271347 | Exon | 0.29(T) | 0.046 | 1.19 × 10-14 | 0.31(T) | 0.121 [27] | 1.62 × 10-13 | 0.11(T) | 0.173 [20] | 3.10 × 10-26 |
ABCG2 | rs4148152 | 4 | 89279933 | Intron | 0.35(C) | −0.029 | 1.22 × 10-7 | 0.19( C) | -- | -- | 0.017(C) | -- | -- |
ABCG2 | rs4148155 | 4 | 89273691 | Intron | 0.29(A) | −0.046 | 9.23 × 10-15 | 0.30(G) | 0.121 [27] | 1.14 × 10-13 | 0.11(A) | −0.170 [20] | 1.50 × 10-25 |
TMEM171 | rs17632159 | 5 | 72467238 | N/A | 0.31(C) | −0.009 | 0.129 | 0.28(C) | −0.045 [25] | 0.011 | 0.31(C) | −0.039 [25] | 3.5 × 10–11 |
VEGFA | rs729761 | 6 | 43912549 | N/A | 0.14(T) | −0.013 | 0.092 | 0.07(T) | 0.002 [25] | 0.97 | 0.30(T) | −0.047 [25] | 8.0 × 10–16 |
LRRC16A | rs742132 | 6 | 25715550 | Intron | 0.25(A) | −0.001 | 0.8705 | 0.31(A) | 0.008 [27] | 0.609 | 0.30(A) | 0.054 [20] | 8.50 × 10-9 |
SLC17A1 | rs1183201 | 6 | 25931423 | Intron | 0.18(A) | −0.009 | 0.2 | 0.16(A) | −0.063 [27] | 1.73 × 10-3 | 0.48(A) | −0.062 [20] | 3.04 × 10-14 |
SLC17A3 | rs1165205 | 6 | 25978521 | Intron | 0.19(T) | −0.010 | 0.139 | 0.16(T) | −0.07 [27] | 5.04 × 10-4 | 0.48(T) | 0.060 [20] | 1.60 × 10-13 |
PRKAG2 | rs10480300b | 7 | 151036938 | Intron | 0.00(T) | -- | -- | 0.00(T) | -- | -- | 0.28(T) | 0.035 [25] | 4.1 × 10–9 |
BAZ1B | rs1178977 | 7 | 72494985 | Intron | 0.08(G) | 0.011 | 0.291 | 0.11(G) | −0.058 [25] | 0.025 | 0.19(G) | −0.047 [25] | 1.2 × 10–12 |
STC1 | rs17786744 | 8 | 23832951 | N/A | 0.35(G) | 0.0001 | 0.989 | 0.25(G) | 0.018 [25] | 0.32 | 0.42(G) | 0.029 [25] | 1.4 × 10–8 |
HNF4G | rs2941484 | 8 | 76641323 | 3utr | 0.32(T) | 0.024 | 1.7× 10-5 | 0.43(T) | 0.050 [25] | 1.8× 10-3 | 0.44(T) | 0.044 [25] | 4.4 × 10–17 |
A1CF | rs10821905 | 10 | 52316099 | 5′near gene | 0.04(A) | 0.008 | 0.584 | 0.05(A) | 0.075 [25] | 0.042 | 0.18(A) | 0.057 [25] | 7.4 × 10–17 |
SLC16A9 | rs12356193b | 10 | 61083359 | Intron | 0.00(C) | -- | -- | 0.00(C) | -- | -- | 0.18(C) | 0.080 [20] | 1.07 × 10-8 |
SLC22A11 | rs17300741 | 11 | 64088038 | Intron | 0.07(A) | 0.018 | 0.087 | 0.03(A) | 0.063 [27] | 0.197 | 0.49(A) | 0.060 [20] | 6.68 × 10-14 |
SLC22A12 | rs505802 | 11 | 64113648 | Intron | 0.23(T) | −0.008 | 0.196 | 0.18(T) | −0.231 [27] | 1.00 × 10-31 | 0.30(T) | −0.060 [20] | 2.04 × 10-9 |
SLC22A12 | rs506338 | 11 | 64197496 | Intron | 0.23(C) | −0.005 | 0.502 | 0.17(C) | −0.229 [27] | 2.34 × 10-31 | 0.29(T) | -- | -- |
ATXN2 | rs653178b | 12 | 110492139 | Intron | 0.00(C) | -- | -- | 0.00(C) | -- | -- | 0.49(C) | 0.035 [25] | 7.2 × 10–12 |
UBE2Q2 | rs1394125 | 15 | 73946038 | Intron | 0.008(A) | 0.014 | 0.188 | 0.08(A) | 0.021 [25] | 0.48 | 0.34(A) | 0.043 [25] | 2.5 × 10–13 |
IGF1R | rs6598541 | 15 | 97088658 | Intron | 0.41(A) | 0.015 | 9.85× 10-3 | 0.50(A) | 0.033 [25] | 0.038 | 0.36(A) | 0.043 [25] | 4.8 × 10–15 |
NFAT5 | rs7193778 | 16 | 68121391 | N/A | 0.05(C) | 0.004 | 0.769 | 0.10(C) | 0.053 [25] | 0.048 | 0.14(C) | 0.046 [25] | 8.2 × 10–10 |
MAF | rs7188445 | 16 | 78292488 | N/A | 0.27(A) | −0.003 | 0.592 | 0.31(A) | −0.06 [25] | 4.5× 10-4 | 0.33(A) | −0.032 [25] | 1.6 × 10–9 |
HLF | rs7224610 | 17 | 50719787 | Intron | 0.13(C) | 0.004 | 0.579 | 0.18(C) | 0.004 [25] | 0.83 | 0.42(C) | 0.042 [25] | 5.4 × 10–17 |