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Table 2 Ethnic differences in major genetic variants associated with serum uric acid levels

From: A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population

      Our study a(Chinese, discovery stage) Japanese European ancestry
Gene SNP Chr Position Location MAF (allele) Effect size P-value MAF (allele) Effect size P-value MAF (allele) Effect size P-value
PDZK1 rs12129861 1 144437046 5′- 0.20(A) −0.011 0.074 0.087(A) -- -- 0.46(A) −0.062 [20] 2.68 × 10-9
TRIM46 rs11264341 1 153418117 Intron 0.33(C) 0.017 4.49 × 10-3 0.24(C) 0.074 [25] 9.5× 10–4 0.43(T) −0.050 [25] 6.2 × 10–19
INHBB rs17050272 2 121022910 N/A 0.45(A) 0.008 0.174 0.49(A) 0.033 [25] 4.4× 10–2 0.43(A) 0.035 [25] 1.6 × 10–10
GCKR rs780094 2 27594741 Intron 0.44(T) 0.0133 0.014 0.43(T) 0.036 [27] 5.12 × 10-6 0.42(T) 0.050 [20] 1.40 × 10-9
LRP2 rs2544390 2 169913092 Intron 0.49(C) −0.001 0.73 0.49(C) −0.082 [27] 3.74 × 10-8 0.37(T) -- --
SFMBT1 rs6770152 3 53075254 N/A 0.36(T) −0.010 0.071 0.46(T) −0.016 [25] 0.31 0.42(G) 0.044 [25] 2.6 × 10–16
SLC2A9 rs11722228 4 9524839 Intron 0.31(T) 0.028 3.68 × 10-6 0.45(T) 0.164 [27] 7.09 × 10-24 0.50(T) 0.167 [20] 1.75 × 10-75
SLC2A9 rs16890979 4 9531265 Exon 0.02(T) −0.024 0.285 0.01(T) −0.178 [27] 3.07 × 10-2 0.29(T) −0.340 [20] 3.55 × 10-189
SLC2A9 rs734553 4 9532102 Intron 0.02(C) −0.023 0.286 0.006(C) -- -- 0.23(C) 0.315 [20] 5.22 × 10-201
ABCG2 rs3114018 4 89283605 Intron 0.38(T) −0.034 2.75 × 10-9 0.26(A) -- -- 0.48(G) −0.057 [20] 2.93 × 10-12
ABCG2 rs2231142 4 89271347 Exon 0.29(T) 0.046 1.19 × 10-14 0.31(T) 0.121 [27] 1.62 × 10-13 0.11(T) 0.173 [20] 3.10 × 10-26
ABCG2 rs4148152 4 89279933 Intron 0.35(C) −0.029 1.22 × 10-7 0.19( C) -- -- 0.017(C) -- --
ABCG2 rs4148155 4 89273691 Intron 0.29(A) −0.046 9.23 × 10-15 0.30(G) 0.121 [27] 1.14 × 10-13 0.11(A) −0.170 [20] 1.50 × 10-25
TMEM171 rs17632159 5 72467238 N/A 0.31(C) −0.009 0.129 0.28(C) −0.045 [25] 0.011 0.31(C) −0.039 [25] 3.5 × 10–11
VEGFA rs729761 6 43912549 N/A 0.14(T) −0.013 0.092 0.07(T) 0.002 [25] 0.97 0.30(T) −0.047 [25] 8.0 × 10–16
LRRC16A rs742132 6 25715550 Intron 0.25(A) −0.001 0.8705 0.31(A) 0.008 [27] 0.609 0.30(A) 0.054 [20] 8.50 × 10-9
SLC17A1 rs1183201 6 25931423 Intron 0.18(A) −0.009 0.2 0.16(A) −0.063 [27] 1.73 × 10-3 0.48(A) −0.062 [20] 3.04 × 10-14
SLC17A3 rs1165205 6 25978521 Intron 0.19(T) −0.010 0.139 0.16(T) −0.07 [27] 5.04 × 10-4 0.48(T) 0.060 [20] 1.60 × 10-13
PRKAG2 rs10480300b 7 151036938 Intron 0.00(T) -- -- 0.00(T) -- -- 0.28(T) 0.035 [25] 4.1 × 10–9
BAZ1B rs1178977 7 72494985 Intron 0.08(G) 0.011 0.291 0.11(G) −0.058 [25] 0.025 0.19(G) −0.047 [25] 1.2 × 10–12
STC1 rs17786744 8 23832951 N/A 0.35(G) 0.0001 0.989 0.25(G) 0.018 [25] 0.32 0.42(G) 0.029 [25] 1.4 × 10–8
HNF4G rs2941484 8 76641323 3utr 0.32(T) 0.024 1.7× 10-5 0.43(T) 0.050 [25] 1.8× 10-3 0.44(T) 0.044 [25] 4.4 × 10–17
A1CF rs10821905 10 52316099 5′near gene 0.04(A) 0.008 0.584 0.05(A) 0.075 [25] 0.042 0.18(A) 0.057 [25] 7.4 × 10–17
SLC16A9 rs12356193b 10 61083359 Intron 0.00(C) -- -- 0.00(C) -- -- 0.18(C) 0.080 [20] 1.07 × 10-8
SLC22A11 rs17300741 11 64088038 Intron 0.07(A) 0.018 0.087 0.03(A) 0.063 [27] 0.197 0.49(A) 0.060 [20] 6.68 × 10-14
SLC22A12 rs505802 11 64113648 Intron 0.23(T) −0.008 0.196 0.18(T) −0.231 [27] 1.00 × 10-31 0.30(T) −0.060 [20] 2.04 × 10-9
SLC22A12 rs506338 11 64197496 Intron 0.23(C) −0.005 0.502 0.17(C) −0.229 [27] 2.34 × 10-31 0.29(T) -- --
ATXN2 rs653178b 12 110492139 Intron 0.00(C) -- -- 0.00(C) -- -- 0.49(C) 0.035 [25] 7.2 × 10–12
UBE2Q2 rs1394125 15 73946038 Intron 0.008(A) 0.014 0.188 0.08(A) 0.021 [25] 0.48 0.34(A) 0.043 [25] 2.5 × 10–13
IGF1R rs6598541 15 97088658 Intron 0.41(A) 0.015 9.85× 10-3 0.50(A) 0.033 [25] 0.038 0.36(A) 0.043 [25] 4.8 × 10–15
NFAT5 rs7193778 16 68121391 N/A 0.05(C) 0.004 0.769 0.10(C) 0.053 [25] 0.048 0.14(C) 0.046 [25] 8.2 × 10–10
MAF rs7188445 16 78292488 N/A 0.27(A) −0.003 0.592 0.31(A) −0.06 [25] 4.5× 10-4 0.33(A) −0.032 [25] 1.6 × 10–9
HLF rs7224610 17 50719787 Intron 0.13(C) 0.004 0.579 0.18(C) 0.004 [25] 0.83 0.42(C) 0.042 [25] 5.4 × 10–17
  1. The NCBI build 36 was used as the reference genome. aSample size, 3451, the P values in Han Chinese population were from meta-analysis of two GWASs (DFTJ-cohort and FAMHES) in discovery stage; --, information is not available. bThese SNP is monoallelic in HapMap CHB and HapMap JPT.