Distribution of the L- and H-signatures in colon and rectal cancer (TCGA_CRC) and endometrial carcinoma (TCGA_EC). X-axis: sample indexes. Y-axis: relative coefficient of the signature. In the L-signature, samples with a microsatellite stable status (MSS, red dots) or low levels of a microsatellite instable status (MSI-L, green dots) have high coefficients in both colon and rectal cancer (A) and endometrial carcinoma samples (B). In the H-signature, samples with high levels of MSI (MSI-H, blue dots) have high coefficient in both colon and rectal cancer (C) and endometrial carcinoma samples (D). Samples with POLE mutations were denoted by large circles.