Coefficient distribution of the L- and H-signatures in samples ordered by MLH1 gene expression level. Top panel: MLH1 gene expression relative to the house-keeping gene, TBP, sorted. Middle panel: the H-signature coefficients in each sample. Samples are listed in the same order as on the top panel. Samples with a high level of MSI are labeled in blue. Bottom panel: the L-signature coefficients in each sample. Samples are in the same order as on the top panel. The figure shows that the samples with a high coefficient of signature #1 had low expression values of MLH1 gene.