Exploring the molecular causes of hepatitis B virus vaccination response: an approach with epigenomic and transcriptomic data

Table 2 Top 10 DM loci obtained with LIMMA

Locus	Gene	Mean β	t-statistic	P-value	Adjusted p-value	B-statistic
cg27427514	-	0.103	-5.541	6.96E-06	0.529	2.195
cg19938535	LRRC16A	0.668	4.980	3.15E-05	1.000	0.808
cg25548594	-	0.322	-4.717	6.39E-05	1.000	0.158
cg01821429	-	0.171	-4.697	6.75E-05	1.000	0.107
cg21899558	PRKAR1B	0.820	4.679	7.09E-05	1.000	0.063
cg01600516	ALOX12	0.690	4.376	1.60E-04	1.000	-0.688
cg26143874	-	0.815	4.252	2.23E-04	1.000	-0.991
cg15773974	-	0.629	4.167	2.81E-04	1.000	-1.201
cg01074767	C1RL; LOC283314	0.597	-4.046	3.87E-04	1.000	-1.495
cg03424554	WWP2	0.467	-3.990	4.49E-04	1.000	-1.633

Column 1 contains the locus ID; Column 2 the gene symbol(s) to which the probe is annotated; Column 3 the average methylation level (β) across all samples; Column 4 moderated t-statistic with standard errors shrunken to a common value; Column 5 nominal p-value; Column 6 multiple testing corrected p-value; column 7 Bayesian odd ratio of DM. In the last column in bold are the odd ratios greater than 0, suggesting differential methylation.

ISSN: 1755-8794