Table 3 Pathways discriminating patients developing delayed graft function (DGF) from those having early graft function (EGF) 24 hours after transplantation (T24)

UP-REGULATED IN DGF

NLS bearing substrate import into nucleus

13

CBLB, FYB, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, NCKIPSD, RANBP5, RERE, TRPS1

<0.001

Regulation of small GTpase mediated signal transduction

24

ABRA, ALS2, ARF6, ARHGAP27, CDC42BPA, CDC42BPB, CDC42BPG, CENTD2, CENTD3, DMPK, FGD1, FGD2, FGD3, FGD4, FGD5, FGD6, MFN2, NF1, NOTCH2, PLCE1, RAC1, RALBP1, RASGRP4, TSC1

0.005

RNA 3 end processing

10

CPSF1, CPSF3, CSTF1, CSTF2, CSTF3, GRSF1, NCBP1, PABPC1, SLBP, TRNT1

0.006

Regulation of RAS protein signal transduction

19

ABRA, ALS2, ARF6, ARHGAP27, CENTD2, CENTD3, FGD1, FGD2, FGD3, FGD4, FGD5, FGD6, MFN2, NF1, NOTCH2, PLCE1, RAC1, RALBP1, RASGRP4, TSC1

0.009

Protein import into nucleus

48

AKT1, BCL3, BCL6, CBLB, CDH1, CEP57, F2, F2R, FAF1, FLNA, FYB, GLI3, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, MCM3AP, MDFI, MXI1, NCKIPSD, NF1, NFKBIE, NFKBIL1, NFKBIL2, NLRP12, NLRP3, NOP5/NOP58, NUP205, PDIA3, PPIH, PPP1R10, PTTG1IP, RANBP2, RANBP5, RERE, RPAIN, SMAD3, TGFB1, TNF, TNFSF14, TNPO1, TPR, TRIP6, TRPS1, ZFYVE9

0.009

DOWN-REGULATED IN DGF

Positive regulation of epithelial cell proliferation

10

EGFR, EPGN, ERBB2, FGF10, LAMA1, LAMB1, LAMC1, NME1, NME2, TGFA

0.003

Rhythmic process

29

AANAT, ARNTL, BMPR1B, CARTPT, CLOCK, CRY1, EGR3, EIF2B2, EIF2B4, EIF2B5, ENOX2, EREG, FOXL2, HEBP1, HTR7, MTNR1A, OPN4, PER1, PER2, PTGDS, SOD1, SPRR2A, SPRR2B, SPRR2C, SPRR2D, SPRR2E, SPRR2F, SPRR2G, TIMELESS

0.004

Negative regulation of translation

23

APBB1, BCL3, EIF2AK1, EIF2AK3, EIF4A3, ELA2, FOXP3, FURIN, GHRL, GHSR, IL10, IL6, INHA, INHBA, INHBB, NDUFA13, NLRP12, PAIP2, PAIP2B, PRG3, SFTPD, SIGIRR, TSC1

0.006

Keratinocyte differentiation

15

ANXA1, CSTA, DSP, EREG, EVPL, IL20, IVL, LOR, NME2, SCEL, SPRR1A, SPRR1B, TGM1, TGM3, TXNIP

0.006

Negative regulation of cytokine biosynthetic process

12

BCL3, ELA2, FOXP3, GHRL, GHSR, IL6, INHA, INHBA, INHBB, NLRP12, SFTPD, SIGIRR

0.008

Negative regulation of biosynthetic process

30

APBB1, BACE2, BCL3, BRCA1, EIF2AK1, EIF2AK3, EIF4A3, ELA2, FOXP3, FURIN, GCK, GHRL, GHSR, GLA, GRM8, IL10, IL6, INHA, INHBA, INHBB, NDUFA13, NLRP12, PAIP2, PAIP2B, PDZD3, PRG3, SFTPD, SIGIRR, SOD1, TSC1

0.009