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Table 1 Characteristics of the hypercholesterolemic and normolipemic groups

From: A genetic variant in the LDLRpromoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia

 

Polygenic hypercholesterolemia (n=477)

Normolipemics (n=525)

P value*

Men (%)

57.4

90.9

< 0.001

Age (years)

51 (41-56)

51 (42-54)

0.004

BMI (kg/m 2 )

26 (24-28)

27 (25-29)

< 0.001

Waist circumference (cm)

92 (84-98)

95 (88-101)

< 0.001

Smoking status (%)

  

0.019

  Active smokers

24.8

37.3

 

  Non-smokers

49.9

37.0

 

  Past smokers

25.3

25.7

 

Hypertension (%)

20.7

20.2

0.885

Laboratory variables (mg/dL)

   

  Fasting glucose

91 (84-98)

94 (87-102)

< 0.001

  Total cholesterol

290 ± 42

202 ± 32

< 0.001

  Triglycerides

108 (83-137)

100 (72-136)

0.019

  HDL-cholesterol

53 (46-65)

53 (47-61)

0.026

  LDL-cholesterol

207 (186-231)

127 (107-147)

< 0.001

  Lipoprotein(a)

29 (13-63)

19 (8-51)

< 0.001

  Apolipoprotein B

148 ± 27

97 ± 22

< 0.001

  1. Data shown for quantitative variable when normal distribution are means ± SD or median and interquartile range for variables with non-normal distribution. Data shown for qualitative variable are percentages. *Calculated by unpaired t-test or Mann–Whitney U–test, as appropriate.
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BMC Medical Genomics

ISSN: 1755-8794

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