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Table 1 Characteristics of the hypercholesterolemic and normolipemic groups

From: A genetic variant in the LDLRpromoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia

  Polygenic hypercholesterolemia (n=477) Normolipemics (n=525) P value*
Men (%) 57.4 90.9 < 0.001
Age (years) 51 (41-56) 51 (42-54) 0.004
BMI (kg/m 2 ) 26 (24-28) 27 (25-29) < 0.001
Waist circumference (cm) 92 (84-98) 95 (88-101) < 0.001
Smoking status (%)    0.019
  Active smokers 24.8 37.3  
  Non-smokers 49.9 37.0  
  Past smokers 25.3 25.7  
Hypertension (%) 20.7 20.2 0.885
Laboratory variables (mg/dL)    
  Fasting glucose 91 (84-98) 94 (87-102) < 0.001
  Total cholesterol 290 ± 42 202 ± 32 < 0.001
  Triglycerides 108 (83-137) 100 (72-136) 0.019
  HDL-cholesterol 53 (46-65) 53 (47-61) 0.026
  LDL-cholesterol 207 (186-231) 127 (107-147) < 0.001
  Lipoprotein(a) 29 (13-63) 19 (8-51) < 0.001
  Apolipoprotein B 148 ± 27 97 ± 22 < 0.001
  1. Data shown for quantitative variable when normal distribution are means ± SD or median and interquartile range for variables with non-normal distribution. Data shown for qualitative variable are percentages. *Calculated by unpaired t-test or Mann–Whitney U–test, as appropriate.