Comparison of mutational classes between primary tumors and metastasis samples. (A) The transition and transversion categories of coding mutations are classified from primary tumor and metastasis-specific groups. (B) Fraction of overall mutations spanning the transition and transversion categories are concluded in primary tumor and metastasis-specific groups. Red boxes represent primary tumor and blue boxes represent metastasis. Asterisks represent significant difference between primary tumor and metastasis (*, 1e-3<P ≤ 5e-2; **, 1e-10<P ≤ 1e-3; ***, P ≤ 1e-10).