Figure 6
From: Whole-genome sequencing of matched primary and metastatic hepatocellular carcinomas
Significantly altered pathway in metastasis. Pathway analysis for metastasis-specific mutant genes identified significant genomic alteration in multiple cancer/cell migration relevant pathways, including (A) tight junction, (B) ErbB/MAPK and (C) focal adhesion pathway. Alterations included somatic SNVs, Indels, CNAs and SVs. Alteration recurrence was referred as number of cases harboring a mutant gene. Alteration types were represented by different colours.