Table 1 Characteristics of study participants
From: Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome
Variable | Batch 1* | Batch 2* | Batch 3^ | Total |
|---|---|---|---|---|
Age at case diagnosis | Â | Â | Â | Â |
N | 69 | 146 | 121 | 336 |
Mean (SD) | 60.2 (12.0) | 63.3 (12.8) | 62.2 (11.3) | 62.3 (12.1) |
Range | (33.0-82.0) | (28.0-91.0) | (33.0-86.0) | (28.0-91.0) |
Age at control enrollment | Â | Â | Â | Â |
N | 87 | 176 | 135 | 398 |
Mean (SD) | 60.2 (12.1) | 62.9 (12.7) | 62.4 (11.4) | 62.2 (12.2) |
Range | (33.0-85.0) | (27.0-89.0) | (33.0-88.0) | (27.0-89.0) |
EOC case vital status | Â | Â | Â | Â |
Alive | 35 (51%) | 51 (35%) | 59 (49%) | 145 (43%) |
Deceased | 34 (49%) | 95 (65%) | 62 (51%) | 191 (57%) |
Follow-up time (years) | Â | Â | Â | Â |
Mean (SD) | 2.8 (1.5) | 4.1 (2.8) | 3.0 (2.5) | 3.4 (2.5) |
Range | (0.1-6.4) | (0.0-11.0) | (0.1-11.4) | (0.0-11.4) |
Parity | Â | Â | Â | Â |
Nulliparous | 25 (16%) | 47 (15%) | 34 (13%) | 106 (14%) |
1-2 | 49 (32%) | 104 (32%) | 109 (43%) | 262 (36%) |
3+ | 77 (50%) | 156 (48%) | 97 (38%) | 331 (45%) |
Unknown | 4 (2%) | 15 (5%) | 16 (6%) | 35 (5%) |
Smoking status | Â | Â | Â | Â |
Never/former | 140 (90%) | 284 (88%) | 213 (83%) | 637 (87%) |
Current | 10 (6%) | 19 (6%) | 20 (8%) | 49 (7%) |
Unknown | 6 (4%) | 19 (6%) | 23 (9%) | 48 (7%) |
Alcohol use | Â | Â | Â | Â |
Current | 93 (60%) | 172 (53%) | 133 (52%) | 398 (54%) |
Former | 22 (14%) | 50 (16%) | 47 (18%) | 119 (16%) |
Never | 34 (22%) | 73 (23%) | 48 (19%) | 155 (21%) |
Unknown | 7 (5%) | 27 (8%) | 28 (11%) | 62 (8%) |
Histology, cases only | Â | Â | Â | Â |
Serous | 46 (66.7%) | 97 (66.4%) | 100 (82.6%) | 243 (72%) |
Endometrioid | 16 (23.2%) | 32 (22%) | 15 (12%) | 63 (19%) |
Clear cell | 4 (5.8%) | 9 (6%) | 3 (3%) | 16 (5%) |
Mucinous | 1 (1.4%) | 4 (3%) | 3 (3%) | 8 (2%) |
Other | 2 (2.9%) | 4 (3%) | 0 (0%) | 6 (2%) |
Grade, cases only | Â | Â | Â | Â |
Grade 1 or 2 | 11 (16%) | 29 (20%) | 16 (13%) | 56 (17%) |
Grade 3 or 4 | 56 (81%) | 117 (80%) | 103 (85%) | 276 (82%) |
Unknown | 2 (3%) | 0 (0%) | 2 (2%) | 4 (1%) |
Stage, cases only | Â | Â | Â | Â |
Stage I or II | 14 (20%) | 39 (27%) | 21 (17%) | 74 (22%) |
Stage III or IV | 55 (80%) | 107 (73%) | 100 (83%) | 262 (78%) |
Surgical debulking, cases only | Â | Â | Â | Â |
Optimal (<1 cm) | 57 (83%) | 123 (84%) | 105 (87%) | 285 (85%) |
Sub-optimal (>1 cm) | 11 (16%) | 22 (15%) | 14 (12%) | 47 (14%) |
Unknown | 1 (1%) | 1 (1%) | 2 (2%) | 4 (1%) |
Ascites, cases only | Â | Â | Â | Â |
No | 39 (57%) | 65 (45%) | 76 (63%) | 180 (54%) |
Yes | 23 (33%) | 42 (29%) | 32 (26%) | 97 (29%) |
Unknown | 7 (10%) | 39 (27%) | 13 (11%) | 59 (18%) |