Skip to main content

Table 1 Characteristics of study participants

From: Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome

Variable Batch 1* Batch 2* Batch 3^ Total
Age at case diagnosis     
N 69 146 121 336
Mean (SD) 60.2 (12.0) 63.3 (12.8) 62.2 (11.3) 62.3 (12.1)
Range (33.0-82.0) (28.0-91.0) (33.0-86.0) (28.0-91.0)
Age at control enrollment     
N 87 176 135 398
Mean (SD) 60.2 (12.1) 62.9 (12.7) 62.4 (11.4) 62.2 (12.2)
Range (33.0-85.0) (27.0-89.0) (33.0-88.0) (27.0-89.0)
EOC case vital status     
Alive 35 (51%) 51 (35%) 59 (49%) 145 (43%)
Deceased 34 (49%) 95 (65%) 62 (51%) 191 (57%)
Follow-up time (years)     
Mean (SD) 2.8 (1.5) 4.1 (2.8) 3.0 (2.5) 3.4 (2.5)
Range (0.1-6.4) (0.0-11.0) (0.1-11.4) (0.0-11.4)
Parity     
Nulliparous 25 (16%) 47 (15%) 34 (13%) 106 (14%)
1-2 49 (32%) 104 (32%) 109 (43%) 262 (36%)
3+ 77 (50%) 156 (48%) 97 (38%) 331 (45%)
Unknown 4 (2%) 15 (5%) 16 (6%) 35 (5%)
Smoking status     
Never/former 140 (90%) 284 (88%) 213 (83%) 637 (87%)
Current 10 (6%) 19 (6%) 20 (8%) 49 (7%)
Unknown 6 (4%) 19 (6%) 23 (9%) 48 (7%)
Alcohol use     
Current 93 (60%) 172 (53%) 133 (52%) 398 (54%)
Former 22 (14%) 50 (16%) 47 (18%) 119 (16%)
Never 34 (22%) 73 (23%) 48 (19%) 155 (21%)
Unknown 7 (5%) 27 (8%) 28 (11%) 62 (8%)
Histology, cases only     
Serous 46 (66.7%) 97 (66.4%) 100 (82.6%) 243 (72%)
Endometrioid 16 (23.2%) 32 (22%) 15 (12%) 63 (19%)
Clear cell 4 (5.8%) 9 (6%) 3 (3%) 16 (5%)
Mucinous 1 (1.4%) 4 (3%) 3 (3%) 8 (2%)
Other 2 (2.9%) 4 (3%) 0 (0%) 6 (2%)
Grade, cases only     
Grade 1 or 2 11 (16%) 29 (20%) 16 (13%) 56 (17%)
Grade 3 or 4 56 (81%) 117 (80%) 103 (85%) 276 (82%)
Unknown 2 (3%) 0 (0%) 2 (2%) 4 (1%)
Stage, cases only     
Stage I or II 14 (20%) 39 (27%) 21 (17%) 74 (22%)
Stage III or IV 55 (80%) 107 (73%) 100 (83%) 262 (78%)
Surgical debulking, cases only     
Optimal (<1 cm) 57 (83%) 123 (84%) 105 (87%) 285 (85%)
Sub-optimal (>1 cm) 11 (16%) 22 (15%) 14 (12%) 47 (14%)
Unknown 1 (1%) 1 (1%) 2 (2%) 4 (1%)
Ascites, cases only     
No 39 (57%) 65 (45%) 76 (63%) 180 (54%)
Yes 23 (33%) 42 (29%) 32 (26%) 97 (29%)
Unknown 7 (10%) 39 (27%) 13 (11%) 59 (18%)
  1. *Assayed using the Illumina Infinium HumanMethylation27 BeadChip.
  2. ^Assayed using the Illumina Infinium HumanMethylation450 BeadChip.