Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome

BMC Medical Genomics

Table 3 CpG sites associated with overall survival following EOC (p < 10 ^-3 )

Probe	Ch	Position (bp)	Nearest genes	Location of nearest gene (bp)^#	Relation to Island^{^}	Meta-Analysis*		Batch 1		Batch 2		Batch 3
						HR	P	HR	P	HR	P	HR	P
cg10276549	X	151143686	GABRE	151121596-151143151	Shore	0.95	5.8E-5	0.96	0.32	0.97	0.19	0.94	2.9E-4
cg06171242	6	24667490	ACOT13	24667263-24705297	Shore	1.10	4.4E-4	1.20	0.22	1.11	7.2E-3	1.02	0.87
cg06171242	6	24667490	TTRAP/TDP2	24650205-24667115	Shore	1.10	4.4E-4	1.20	0.22	1.11	7.2E-3	1.02	0.87
cg14360897	17	4843676	RNF167	4843630-4848517	Shore	1.22	5.9E-4	1.25	0.084	1.29	3.8E-3	1.13	0.20
cg14360897	17	4843676	SLC25A11	4840425-4843462	Shore	1.22	5.9E-4	1.25	0.084	1.29	3.8E-3	1.13	0.20
cg26802333	16	56716182	MT1X	56716382-56718108	Island	1.07	7.4E-4	1.11	0.044	1.07	1.2E-3	1.00	0.97
cg03729431	17	15848264	ADORA2B	15848231-15879210	Island	1.11	7.5E-4	0.97	0.85	1.12	5.8E-3	1.09	0.69
cg21858376	3	4534791	ITPR1	4535032-4889524	Island	1.12	7.9E-4	1.31	0.11	1.11	0.022	1.09	0.37
cg12003230	21	44899139	C21orf84/	44881974-44898103		0.86	8.1E-4	0.82	0.022	0.85	8.9E-3	0.97	0.72
cg12003230	21	44899139	LINC00313	44881974-44898103		0.86	8.1E-4	0.82	0.022	0.85	8.9E-3	0.97	0.72
cg05026186	5	148520876	ABLIM3	148521054-148639999	Shore	0.96	9.3E-4	0.98	0.41	0.96	5.3E-3	0.96	0.071

^#Locations based on NCBI (http://www.ncbi.nlm.nih.gov), build 37.
^Shore CpG sites defined to be within +/- 2 kb from CpG island; Shelf CpG sites defined to be within +/- 2kb of CpG Shore.
*All tests for heterogeneity of effects across the three batches were non-significant (p > 0.05); analysis adjusted for age at diagnosis, tumor stage, presence of ascites and volume of residual tumor following debulking surgery.

ISSN: 1755-8794