Figure 2

Assignment of psoriasis DEGs and GWAS candidates to cell types present in lesional skin. Human genes were assigned to one of 10 cell types present in psoriasis lesions. Genes were assigned to the cell type for which median expression was highest, provided that the gene’s expression was detected in at least 10% of microarray samples for that cell type (P < 0.05, Wilcoxon signed-rank test). If a gene’s expression was not detected with respect to at least 10% of microarray samples for any cell type, no assignment was made (i.e., unassigned). Pie charts show the percentage of PP-increased DEGs (top), PP-decreased DEGs (middle) and GWAS candidates (bottom) that were either unassigned or allocated to one of the 10 cell types. Magenta labels denote those cell types for which the number of assigned genes was significantly large in comparison to all skin-expressed genes (PP-increased and PP-decreased DEGs) or in comparison to all genes represented on the Affymetrix Human Genome U133 Plus 2.0 array platform (GWAS candidates) (one asterisk, P < 0.05; two asterisks, FDR < 0.05; Fisher’s Exact Test).