Figure 4

Cluster analysis of 885 genes decreased in psoriasis lesions and their expression across 10 cell types. We identified 885 PP-decreased DEGs with PP/PN fold-change less than 0.67 and FDR less than 0.05 (n = 216 patients; Wilcoxon rank sum test). These genes were clustered based upon their expression pattern across 10 cell types (Spearman correlation distance metric and average linkage). The red-blue heatmap shows the expression of each gene in each cell type, with red colors indicating relatively high expression (compared to normal human skin) and blue colors indicating relatively low expression (compared to normal human skin). The yellow-black heatmap shows the cell type assigned to each gene (highest median expression with detection frequency greater than 10%). The chart on the far right shows the estimated median fold-change (PP/PN) for each gene (n = 216 patients).