Figure 5

Top 30 GWAS candidates with altered expression in psoriasis lesions and their expression across 10 cell types. The table lists the 30 psoriasis GWAS candidates for which expression was most strongly altered in psoriasis lesions (i.e., lowest p-value, Wilcoxon rank sum test; n = 216 patients). Each of the listed genes was skin-expressed, with expression detected above background with respect to at least 10% of the 432 PP and PN skin samples from all 216 patients. The color scale denotes median expression of each gene, as compared to the gene’s median expression in normal human skin. Red colors thus denote expression that is higher in comparison to normal human skin, while blue colors indicate that expression is lower in comparison to normal human skin. For each gene and cell type, black circles indicate the percentage of microarray samples for which the gene’s expression was detected above background (P < 0.05, Wilcoxon signed-rank test). Red labels (left margin) denote PP-increased DEGs (FDR < 0.05 with median PP/PN fold-change > 1.5), while blue labels (left margin) represent PP-decreased DEGs (FDR < 0.05 with median PP/PN fold-change < 0.67). The cell type assigned to each gene is listed in the right margin. Magenta labels denote cases in which the gene’s expression in the assigned cell type is significantly higher than its expression in any of the other 9 cell types (FDR < 0.05, Wilcoxon rank sum test).