Figure 6

Cell type assignments for 105 psoriasis GWAS candidate genes. The left margin lists each individual gene, the assigned cell type, and the gene’s detection frequency with respect to that cell type (KC = keratinocytes; FB = fibroblasts; CD4 = CD4+ T-cells; NK = NK Cells; CD8 = CD8+ T-cells; B = B-cells; MP = macrophage; MC = monocyte; DC = dendritic cells; NP = neutrophils). Genes are ranked by the degree to which they showed specific expression in the assigned cell type. To obtain the p-value shown for each gene, expression in the assigned cell type was compared to expression in each of the other nine cell types, respectively (n = 50 samples per cell type; Wilcoxon rank sum test). The p-value shown for each gene corresponds to the largest p-value obtained from each of the 9 comparisons to other cell types (asterisk, FDR < 0.05).