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Table 2 Summary of blood eQTL overlap with each brain eQTL study

From: Overlap of expression Quantitative Trait Loci (eQTL) in human brain and blood

Study Number of overlapping eQTL Percentage of genes in blood with overlapping eQTL in brain study Percentage of genes in brain study with overlapping eQTL in blood Mean number of overlapping SNPs per gene Mean R2(blood)1 Mean R2(brain study)1 Mean distance (kb) of overlapping SNP from probe1
CIS
Colantuoni et al. [17] 94 (12) 1.9 (0.2) 20.1 (2) 5.5 0.14 Data unavailable 18.6
Gibbs et al. [12] 697 (34) 14.2 (0.6) 70 (3.4) 15.7 0.19 0.32 62.8
Heinzen et al. [7] 7 (0) 0.15 (0) 13 (0) 11.1 0.11 0.14 48.1
Kim et al. [18] 66 (8) 1.3 (0.1) 10 (1.2) 7.6 0.15 Data unavailable 39.7
Liu et al. [19] 59 (7) 1.2 (0.1) 5.7 (0.8) 4.8 0.10 0.15 25.1
Myers et al. [22] 507 (49) 10.3 (1) 17 (1.7) 7.1 0.13 Data unavailable 18.5
Webster et al. [20] 133 (17) 2.7 (0.3) 18 (2.2) 3.4 0.12 0.19 AD 69.0
0.15 Controls
Zou et al. [21] 156 (16) 3.1 (0.3) 23 (2.3) 5.6 0.13 0.223 26.12
CIS AND TRANS  
Gibbs et al. [12] 712 (38) 14.3 (0.6) 0.71 (3.4) 15.8 0.18 0.32  
Kim et al. [18] 69 (8) 1.4 (0.1) 10.6 (1.2) 7.8 0.14 Data unavailable  
Liu et al. [19] 61 (7) 1.2 (0.1) 5.7 (0.8) 4.3 0.11 0.15  
Myers et al. [22] 542 (54) 10.3 (1) 18 (1.7) 7.6 0.14 Data unavailable  
Webster et al. [20] 142 (19) 2.7 (0.3) 19 (2.2) 3.1 0.14 0.18 AD  
0.13 Controls
  1. 1Only for identical SNP:Gene associations.
  2. 2Cis = ± 100 kb.
  3. 3Only 139/514 (27.0%) of SNP:Gene associations had R2 data.
  4. R2 is the proportion of transcript level variance explained by the overlapping SNP.
  5. AD – Late-onset Alzheimer’s disease.
  6. Numbers shown in brackets indicate contribution of proxy SNPs to total value. The numbers in parentheses are those found using proxy SNPs.