Table 5 Summary of Westra et al.[32] blood eQTL overlap with eQTL from Webster et al .[29] which were found to have an interaction with late-onset Alzheimer’s disease (AD) status as well as those independent of disease status
From: Overlap of expression Quantitative Trait Loci (eQTL) in human brain and blood
Effect of diagnosis | Number of overlapping eQTL | Percentage of genes in blood with overlapping eQTL in Webster et al. | Percentage of genes in Webster et al. with overlapping eQTL in blood | Mean number of overlapping SNPs per gene | Mean R 2(blood)1 | Mean R 2(Webster et al.)1 | Mean distance (kb) of overlapping eSNP from TSS1 |
|---|---|---|---|---|---|---|---|
AD interaction | 67 (1) | 1.3 (0) | 9 (0.1) | 1.4 | 0.12 | 0.20 Cases | 78.4 |
0.09 Controls | |||||||
No interaction | 111 (14) | 2.2 (1) | 15 (1.8) | 4.0 | 0.12 | 0.15 Cases | 52.9 |
0.13 Controls |