Figure 1

Overlapping somatic mutations between exome-seq and mRNA-seq. A. The number of somatic mutations from exome-seq (blue), mRNA-seq (green), and overlap between the two (red) for each tumor. B. Mutated allele frequency in tumor from exome and mRNA-seq. The frequency is mostly higher and is preferentially expressed in mRNA. The red dot is for EGFR mutation in 4 tumors, all higher in mRNA. Green line – linear trend line for the mutation allele frequency between DNA and mRNA. Black line – expected diagonal line if the frequencies were the same between DNA and mRNA.