Association of pathway deregulation with mutation profiles and patient survival. A. Unsupervised clustering for tumors by pathway deregulation score and their association with 10 genes with recurrent mutations. B. Kaplan Meier survival curve by sample cluster defined by pathway deregulation score comparing Cluster 3 vs. Cluster 1, 2. C. Differentially deregulated pathways between patients with bad (cluster 3) and those with good survivals (cluster 1 and 2). X-axis: mean pathway score difference. Y-axis: negative log10 p value. The samples with bad survival had more pathways with a higher deregulation score.