Two-dimensional heatmap of chromatin interaction in the neighbourhood of the rs12087869 SNP. The figure shows Hi-C chromatin interaction datasets in H1 human ES cells (upper) and IMR90 fibroblast cells (lower panel) obtained from Dixon et al. in the neighbourhood of the rs12087869 SNP. The topological domains (TADs) from both cell types were shown to indicate genomic neighbourhood of stronger within-domain interactions. The heatmap values indicated in a color scale correspond to the number of times that reads in two 20 kb bins were sequenced as a pair, with the red color indicating stronger interaction and white being little or no interaction. The 85 percentile read counts (29 for H1 and 21 for IMR90 cells) were used as the upper limit for the heatmap to avoid color domination of extremely interactive regions. This plot was generated using ‘HiTC’ R package, and the dotted lines were drawn to aid in visualizing the interactive domain in which the SNP is located. The TAD region (from H1 cells) containing the SNP is highlighted in a light pink box.