Figure 2

Effect of drug treatment on cardiac parameters of LDLr-/- mice. Heart weight (A), gene expression of cardiac stress marker Bnp (B), and Anp (C) assessed by RT-PCR, and quantitative analysis of atherosclerotic lesions in the aortic root area (D). Values are mean ± SEM. # indicates statistical significance P < 0.05 compared to chow, *indicates statistical significance P < 0.05 compared to HF-diet.