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Table 5 Class characterization summary a

From: Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics

Analysis Characterization Description Class 1 Class 2 P-vale
Dura Biologicalb Dorso-ventral axis formation 3/3 Up 3/3 Down 0.001
   Pathways in cancer 4/6 Up 4/6 Down 0.031
  Radiologicalc Area3 Larger Smaller 0.006
   Supraoccipital bone Larger Smaller 0.006
   Opisthion to reference Larger Smaller 0.046
  Clinical NA NA NA NA
Blood Biologicalb Ribosome 10/10 Up 10/10 Down 2.80E-09
   Spliceosome 5/6 Up 5/6 Down 0.005
   Proteosome 3/3 Up 3/3 Down 0.007
   RNA degradation 2/3 Up 2/3 Down 0.014
   Oxidative phosphorylation 2/4 Up 2/4 Down 0.018
  Radiologicalc Boogaard’s angle Smaller Larger 0.004
   Basion to reference Larger Smaller 0.016
   Tentorium Smaller Larger 0.036
  Clinicald Paternal age Younger Older 0.021
  1. aOnly nominally significant results are shown. In addition, only the two most significant clustering analyses were included in the table.
  2. bThe top 100 ranked genes from each analysis were used as input into DAVID v6.7 for the pathway analysis. KEGG pathways with a Fisher exact p < 0.05 are listed. Additional filtering was applied using DAVID's default settings: minimum of 2 genes present in the pathway and an EASE score < 0.1. For each class, the total number of genes present in each pathway and whether they are down- or up-regulated with respect to the other class are noted.
  3. cLogistic regression was carried out including age at MRI, sex, and race as covariates in the model.
  4. dA t-test assuming equal variance was performed.
  5. eThese are not adjusted for multiple testing.