Figure 5From: Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy Akt signaling pathway. The Akt signaling pathway in IPA. Blue: significantly lower, orange: significantly higher phosphorylation in osteosarcoma cell lines, gray, no significant difference in phosphorylation, white: no phosphorylation sites of the particular protein on the PamGene Ser/Thr chip. Blue lines indicate known downstream phosphorylation by the upstream kinase.Back to article page