Figure 3

Consensus network of the 24 differentially expressed genes (DEGs). The model contains nodes representing the 4 stimuli and the 24 selected DEGs. The heuristic optimization leads to an optimal fit of the model to the measured data and is preferably based on inferred edges supported by prior knowledge (represented in green). Edges ‘externally’ validated by additional knowledge are emphasized by green double-line edges. However, the model also contains edges only predicted from the expression data (represented in black) and one edge conflicting with prior knowledge (represented in red).