Gene-interaction network. Genes associated with the significantly enriched GO terms were analyzed by gene-interaction network, which was built according to the relationships among genes, proteins, and compounds in the KEGG database. Circles, squares, and triangles represent, respectively, genes differentially regulated in both mild ICP and severe ICP (Intersection), mild ICP only, and severe ICP only. Red and green represent genes that were differentially up-regulated or down-regulated, respectively. Detailed gene-gene relationships with the degree of each gene are shown in Additional file 3: Spreadsheet S1.