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Table 3 Changed mRNAs in rat ARDS

From: MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome

Gene

Full name

Fold change

q-value

Mt3

Metallothionein 3

43.49

<0.05

S100a9

S100 calcium binding protein A9 (calgranulin B)

6.81

<0.05

Prdx6

Peroxiredoxin-6

5.89

<0.05

TIMP1

Metalloproteinase inhibitor 1

5.79

<0.05

Ccl2

Chemokine (C-C motif) ligand 2

3.90

<0.05

Sod2

Superoxide dismutase 2, mitochondrial

2.98

<0.05

Lcn2

Lipocalin 2

2.59

<0.05

Ifrd1

Interferon-related developmental regulator 1

2.16

<0.05

Apc

Adenomatosis polyposis coli

2.02

<0.05

Ebf1

Early B-cell factor 1

2.00

<0.05

Mt2a

metallothionein-2 and metallothionein-1 genes

2.00

<0.05

Cyb5

Cytochrome b5

0.52

<0.05

L20990

T cell receptor

0.51

<0.05

Serpinh1

Serine (or cysteine) proteinase inhibitor, clade H, member 1

0.5

<0.05

S100a4

S100 calcium-binding protein A4

0.49

<0.05

Eif2ak1

Eukaryotic translation initiation factor 2-alpha kinase 1

0.49

<0.05

Fbln5

Fibulin 5

0.48

<0.05

Aco2

Aconitase 2, mitochondrial

0.48

<0.05

Akr1b4

Aldo-keto reductase family 1, member B4 (aldose reductase)

0.47

<0.05

Lct

Lactase-phlorizinhydrolaseLactasePhlorizin hydrolase

0.47

<0.05

Slc25a11

Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), Member 11

0.47

<0.05

Ramp2

Receptor (calcitonin) activity modifying protein 2

0.47

<0.05

G8

G8 gene

0.46

<0.05

Acaa2

Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)

0.43

<0.05

Gabrb1

Gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1

0.43

<0.05

M13801

Ig germline alpha H-chain C-region gene

0.42

<0.05

Septin 5

Septin 5

0.4

<0.05

Mdh1

Malate dehydrogenase 1, NAD (soluble)

0.39

<0.05

Psma4

Proteasome (prosome, macropain) subunit, alpha type 4

0.39

<0.05

Alad

Aminolevulinate, delta-, dehydratase

0.38

<0.05

Igfbp6

Insulin-like growth factor binding protein 6

0.37

<0.05

Ces3

Carboxylesterase 3

0.35

<0.05

U06230

protein S mRNA

0.31

<0.05

Fgfr4

Fibroblast growth factor receptor subtype 4 (FGFR4) mRNA

0.27

<0.05

Lim2

Lens intrinsic membrane protein 2

0.24

<0.05

Tspan8

Tetraspanin 8

0.24

<0.05

Gnrh1

Progonadoliberin-1Gonadoliberin-1Prolactin release-inhibiting factor 1

0.08

<0.05

  1. A list of increased and decreased mRNAs in rat ARDS (n = 4 animals) when compared to normal lung samples (n = 4 animals) with a q value of < 0.05 (SAM) and a fold change of ≥ 2.
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BMC Medical Genomics

ISSN: 1755-8794

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