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Table 4 Functional annotation clustering of up-regulated genes

From: MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome

Annotation cluster 1 Enrichment score: 2.44    
Category Term Count % P value
GOTERM_BP_FAT GO:0019725 ~ cellular homeostasis 5 56 < 0.001
GOTERM_BP_FAT GO:0055066 ~ di-, tri-valent inorganic cation homeostasis 3 33 0.003
GOTERM_BP_FAT GO:0055080 ~ cation homeostasis 3 33 0.005
GOTERM_BP_FAT GO:0006873 ~ cellular ion homeostasis 3 33 0.010
GOTERM_BP_FAT GO:0055082 ~ cellular chemical homeostasis 3 33 0.010
GOTERM_BP_FAT GO:0050801 ~ ion homeostasis 3 33 0.012
GOTERM_BP_FAT GO:0048878 ~ chemical homeostasis 3 33 0.018
Annotation cluster 2 Enrichment score: 1.82    
GOTERM_BP_FAT GO:0043066 ~ negative regulation of apoptosis 3 33 0.008
GOTERM_BP_FAT GO:0043069 ~ negative regulation of programmed cell death 3 33 0.008
GOTERM_BP_FAT GO:0060548 ~ negative regulation of cell death 3 33 0.008
GOTERM_BP_FAT GO:0030097 ~ hemopoiesis 3 33 0.009
GOTERM_BP_FAT GO:0048534 ~ hemopoietic or lymphoid organ development 3 33 0.011
GOTERM_BP_FAT GO:0002520 ~ immune system development 3 33 0.012
GOTERM_BP_FAT GO:0042981 ~ regulation of apoptosis 3 33 0.039
GOTERM_BP_FAT GO:0043067 ~ regulation of programmed cell death 3 33 0.040
GOTERM_BP_FAT GO:0010941 ~ regulation of cell death 3 33 0.041
  1. The functional annotation of mRNA expression profile was conducted by DAVID software (http://david.abcc.ncifcrf.gov) [30, 31]. Annotation Cluster: a group of terms having similar biological functions. Enrichment Score: The geometric mean (in -log scale) of member's p-values in a corresponding annotation cluster is the rank of their biological significance. The higher an enrichment score, the more enriched genes in that group. An enrichment score of >1.3 is used for a cluster to be statistically significant. P-Value: The p-values associated with each annotation terms are the Fisher Exact Score shown in the regular chart report for the same terms. Count: Genes involved in the terms. %: Percentage of involved genes over total up-regulated genes correlated to altered miRNAs.