Skip to main content

Table 4 Functional annotation clustering of up-regulated genes

From: MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome

Annotation cluster 1

Enrichment score: 2.44

   

Category

Term

Count

%

P value

GOTERM_BP_FAT

GO:0019725 ~ cellular homeostasis

5

56

< 0.001

GOTERM_BP_FAT

GO:0055066 ~ di-, tri-valent inorganic cation homeostasis

3

33

0.003

GOTERM_BP_FAT

GO:0055080 ~ cation homeostasis

3

33

0.005

GOTERM_BP_FAT

GO:0006873 ~ cellular ion homeostasis

3

33

0.010

GOTERM_BP_FAT

GO:0055082 ~ cellular chemical homeostasis

3

33

0.010

GOTERM_BP_FAT

GO:0050801 ~ ion homeostasis

3

33

0.012

GOTERM_BP_FAT

GO:0048878 ~ chemical homeostasis

3

33

0.018

Annotation cluster 2

Enrichment score: 1.82

   

GOTERM_BP_FAT

GO:0043066 ~ negative regulation of apoptosis

3

33

0.008

GOTERM_BP_FAT

GO:0043069 ~ negative regulation of programmed cell death

3

33

0.008

GOTERM_BP_FAT

GO:0060548 ~ negative regulation of cell death

3

33

0.008

GOTERM_BP_FAT

GO:0030097 ~ hemopoiesis

3

33

0.009

GOTERM_BP_FAT

GO:0048534 ~ hemopoietic or lymphoid organ development

3

33

0.011

GOTERM_BP_FAT

GO:0002520 ~ immune system development

3

33

0.012

GOTERM_BP_FAT

GO:0042981 ~ regulation of apoptosis

3

33

0.039

GOTERM_BP_FAT

GO:0043067 ~ regulation of programmed cell death

3

33

0.040

GOTERM_BP_FAT

GO:0010941 ~ regulation of cell death

3

33

0.041

  1. The functional annotation of mRNA expression profile was conducted by DAVID software (http://david.abcc.ncifcrf.gov) [30, 31]. Annotation Cluster: a group of terms having similar biological functions. Enrichment Score: The geometric mean (in -log scale) of member's p-values in a corresponding annotation cluster is the rank of their biological significance. The higher an enrichment score, the more enriched genes in that group. An enrichment score of >1.3 is used for a cluster to be statistically significant. P-Value: The p-values associated with each annotation terms are the Fisher Exact Score shown in the regular chart report for the same terms. Count: Genes involved in the terms. %: Percentage of involved genes over total up-regulated genes correlated to altered miRNAs.