MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome

BMC Medical Genomics

Table 5 Functional annotation clustering of down-regulated genes

Annotation cluster 1	Enrichment score: 1.38
Category	Term	Count	%	P value
SP_PIR_KEYWORDS	Disulfide bond	8	38	0.014
SP_PIR_KEYWORDS	Glycoprotein	9	43	0.034
UP_SEQ_FEATURE	Signal peptide	8	38	0.035
SP_PIR_KEYWORDS	Signal	8	38	0.037
UP_SEQ_FEATURE	Glycosylationsite: N-linked (GlcNAc…)	8	38	0.072
UP_SEQ_FEATURE	Disulfide bond	6	29	0.117

The functional annotation of mRNA expression profile was conducted by DAVID software (http://david.abcc.ncifcrf.gov) [30, 31]. Annotation Cluster: A group of terms having similar biological functions. Enrichment Score: The geometric mean (in -log scale) of member's p-values in a corresponding annotation cluster represents the rank of their biological significance. An enrichment score of >1.3 is used for a cluster to be statistically significant. The higher an enrichment score, the more enriched genes in that group. P-Value: The p-values associated with each annotation terms are the Fisher Exact Score shown in the regular chart report for the same terms. Count: Genes involved in the terms. %: Percentage of involved genes over total down-regulated genes correlated to altered miRNAs.

ISSN: 1755-8794