Table 6 GO enrichments of the down-regulated genes in ARDS using STRING analysis

Biological process

GO:0046501

Protoporphyrinogen IX metabolic process

2

1.15E-04

Eif2ak1, Alad

GO:0030198

Extracellular matrix organization

2

4.84E-03

Ramp2, Flbn5

GO:0043062

Extracellular structure organization

2

4.84E-03

Ramp2, Flbn5

GO:0044242

Cellular lipid catabolic process

2

5.73E-03

Acaa2, Ces3

GO:0046777

Protein autophosphorylation

2

8.67E-03

Eif2ak1, Fgfr4

GO:0030162

Regulation of proteolysis

2

1.25E-02

Serpinh1, Fgfr4

GO:0055114

Oxidation-reduction process

3

1.33E-02

Acaa2, Cyb5, Mdh1

GO:0070613

Regulation of protein processing

2

1.70E-02

Serpinh1, Fgfr4

GO:0045471

Response to ethanol

2

1.90E-02

Gnrh1, Lct

GO:0016042

Lipid catabolic process

2

1.90E-02

Acaa2, Ces3

GO:0080134

Regulation of response to stress

3

2.22E-02

Eif2ak1, Fbln5, Tspan8

GO:0051186

Cofactor metabolic process

2

2.69E-02

Eif2ak1, Acaa2

GO:0080135

Regulation of cellular response to stress

2

3.49E-02

Eif2ak1, Fbln5

GO:0071363

Cellular response to growth factor stimulus

2

3.94E-02

Ramp2, Fgfr4

GO:0048583

Regulation of response to stimulus

5

4.70E-02

Ramp2, Flbn5, Eif2ak1, Fgfr4, Tspan8

GO:0070848

Response to growth factor

2

4.81E-02

Ramp2, Fgfr4

Molecular function

GO:0016836

Hydro-lyase activity

2

0.000481

Aco2, Alad

GO:0016835

Carbon-oxygen lyase activity

2

0.00106

Aco2, Alad

GO:0016829

Lyase activity

2

0.0102

Aco2, Alad

GO:0020037

Heme binding

2

0.0153

Eif2ak1, Cyb5

GO:0046906

Tetrapyrrole binding

2

0.0164

Eif2ak1, Cyb5

GO:0044822

Poly(A) RNA binding

4

0.0255

Serpinh1, S100a4, Acaa2, Slc25a11

GO:0003723

RNA binding

4

0.0313

Serpinh1, S100a4, Acaa2, Slc25a11

Cellular component

GO:0005788

Endoplasmic reticulum lumen

2

2.38E-03

Ces3, serpineh 1

GO:0044432

Endoplasmic reticulum part

3

3.15E-02

Ces3, serpineh 1, Cyb5

GO:0005739

Mitochondrion

4

3.94E-02

Aco2, Mdh1, Slc25a11, Acaa2