Distribution of the features used in the final prediction model over benign and deleterious mutations. A. Abs_dSS – absolute difference between similarity scores of wild type amino acid and mutation for a given position. B. ss_Abs_dSize – absolute difference between sizes of wild type amino acid and mutation weighted by the difference of the corresponding similarity scores. C. zsEntropy21 – Z-score for Shannon entropy at a given position based on a window of 21 neighboring amino acids. D. predRSA – predicted RSA. E. varPredRSA21 – variance of predicted RSA for the window of 21 neighboring amino acids. Whiskers indicate minimal and maximal values of a given feature.