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Table 5 Performance of the evaluated methods on the blind set (BS292)

From: MutaCYP: Classification of missense mutations in human cytochromes P450

Methoda Predicted mutation status Correlation,r
Benign Deleterious PolyPhen-2 HumVar PolyPhen-2 HumDiv SIFT
MutaCYP 115 177 0.48 0.48 0.34
PolyPhen-2 HumVar 170 122   0.96 0.47
PolyPhen-2 HumDiv 162 130    0.48
SIFT 161 124    
  1. aSIFT predictions miss 7 mutations.