Figure 4
CD4+ lymphocyte coexpression network with detail of the brown coexpression module. A. Each circle represents a gene. Weighted gene coexpression analysis identified groups of genes with similar patterns of gene expression and interconnectivity (coexpression modules). The 41 coexpression modules identified are labeled by color. Pathways associated with the largest coexpression modules are denoted in the legend. B. Interconnectivity of the brown coexpression module is shown in detail. Tagged by 6 allergic rhinitis GWAS loci, this coexpression module was highly enriched for allergic rhinitis-associated eSNPs (3.4-fold enrichment, FDR-adjusted P value = 2.6 × 10−24) and also highly enriched for pathways related to mitochondrial function (8.6-fold enrichment, FDR-adjusted P value = 4.5 × 10−72). Genes containing allergic rhinitis-associated eSNPs are marked in brown, with those containing eSNPs with lowest P-value for association between genotype and gene expression marked with greatest brown saturation. Genes in pathways related to mitochondrial function are marked by diamonds with blue outline. Higher correlation between gene expression is shown with thicker and darker edges.