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Table 2 Up-regulated genes related with functions and phenotypes of CIK IL-15

From: Global transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor

Gene symbol Description Log2FC P value FDR Go Term
Wnt 4 Protein Wnt-4 1.10 3.61 × 10−4 7.28 × 10−3 Regulation of cell-cell adhesion; Wnt signaling pathway; immature T cell proliferation in thymus; positive regulation of focal adhesion assembly; T cell differentiation in thymus; cell differentiation; cell-cell signaling; negative regulation of apoptotic process; positive regulation of transcription, DNA-templated
IL21R Interleukin 21 receptor 1.17 2.53 × 10−4 5.53 × 10−3 Interleukin-21-mediated signaling pathway; natural killer cell activation; cytokine-mediated signaling pathway
DTX4 E3 ubiquitin-protein ligase 2.65 2.02 × 10−3 2.82 × 10−2 Regulation of type I interferon production; positive regulation of type I interferon production; Notch signaling pathway; innate immune response; protein ubiquitination
ICAM4 Intercellular adhesion molecule 4 1.90 1.46 × 10−4 3.51 × 10−3 Cell adhesion; cell-cell adhesion; regulation of immune response
PDGFD Platelet-derived growth factor D 1.65 2.38 × 10−5 8.11 × 10−4 Platelet-derived growth factor receptor signaling pathway; cellular response to amino acid stimulus; multicellular organismal development; regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division