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Table 2 Up-regulated genes related with functions and phenotypes of CIK IL-15

From: Global transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor

Gene symbol

Description

Log2FC

P value

FDR

Go Term

Wnt 4

Protein Wnt-4

1.10

3.61 × 10−4

7.28 × 10−3

Regulation of cell-cell adhesion; Wnt signaling pathway; immature T cell proliferation in thymus; positive regulation of focal adhesion assembly; T cell differentiation in thymus; cell differentiation; cell-cell signaling; negative regulation of apoptotic process; positive regulation of transcription, DNA-templated

IL21R

Interleukin 21 receptor

1.17

2.53 × 10−4

5.53 × 10−3

Interleukin-21-mediated signaling pathway; natural killer cell activation; cytokine-mediated signaling pathway

DTX4

E3 ubiquitin-protein ligase

2.65

2.02 × 10−3

2.82 × 10−2

Regulation of type I interferon production; positive regulation of type I interferon production; Notch signaling pathway; innate immune response; protein ubiquitination

ICAM4

Intercellular adhesion molecule 4

1.90

1.46 × 10−4

3.51 × 10−3

Cell adhesion; cell-cell adhesion; regulation of immune response

PDGFD

Platelet-derived growth factor D

1.65

2.38 × 10−5

8.11 × 10−4

Platelet-derived growth factor receptor signaling pathway; cellular response to amino acid stimulus; multicellular organismal development; regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division

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BMC Medical Genomics

ISSN: 1755-8794

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