Table 3 Up-regulated genes related with functions and phenotypes of CIK _IL-2

CTLA4

Cytotoxic T-lymphocyte-associated protein 4

1.01

1.64 × 10⁻³

2.38 × 10⁻²

Immune response; negative regulation of regulatory T cell differentiation; negative regulation of B cell proliferation; T cell costimulation; B cell receptor signaling pathway; cellular response to DNA damage stimulus; positive regulation of apoptotic process

CD80

CD80 antigen

1.03

1.11 × 10⁻³

1.75 × 10⁻²

Innate immune response; positive regulation of GMCSF biosynthetic process; positive regulation of T-helper 1 cell differentiation; T cell activation; regulation of interleukin-2 biosynthetic process; T cell costimulation

TNFSF10

Tumor necrosis factor ligand superfamily member 10

1.24

7.02 × 10⁻¹⁸

4.45 × 10⁻¹⁵

Immune response; activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of extrinsic apoptotic; signaling pathway in absence of ligand; apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process

CD40L

CD40 ligand

2.08

2.32 × 10⁻⁶

1.18 × 10⁻⁴

Immune response; inflammatory response; immunoglobulin secretion; positive regulation of endothelial cell apoptotic process; B cell proliferation; positive regulation of interleukin-12 production; leukocyte cell-cell adhesion

IRF7

Interferon regulatory factor 7

1.08

3.12 × 10⁻⁵

1.02 × 10⁻³

Innate immune response; inflammatory response; positive regulation of type I interferon-mediated signaling pathway; positive regulation of type I interferon production; toll-like receptor signaling pathway