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Table 3 Up-regulated genes related with functions and phenotypes of CIK IL-2

From: Global transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor

Gene symbol Description Log2FC P value FDR Go terms
CTLA4 Cytotoxic T-lymphocyte-associated protein 4 1.01 1.64 × 10−3 2.38 × 10−2 Immune response; negative regulation of regulatory T cell differentiation; negative regulation of B cell proliferation; T cell costimulation; B cell receptor signaling pathway; cellular response to DNA damage stimulus; positive regulation of apoptotic process
CD80 CD80 antigen 1.03 1.11 × 10−3 1.75 × 10−2 Innate immune response; positive regulation of GMCSF biosynthetic process; positive regulation of T-helper 1 cell differentiation; T cell activation; regulation of interleukin-2 biosynthetic process; T cell costimulation
TNFSF10 Tumor necrosis factor ligand superfamily member 10 1.24 7.02 × 10−18 4.45 × 10−15 Immune response; activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of extrinsic apoptotic; signaling pathway in absence of ligand; apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process
CD40L CD40 ligand 2.08 2.32 × 10−6 1.18 × 10−4 Immune response; inflammatory response; immunoglobulin secretion; positive regulation of endothelial cell apoptotic process; B cell proliferation; positive regulation of interleukin-12 production; leukocyte cell-cell adhesion
IRF7 Interferon regulatory factor 7 1.08 3.12 × 10−5 1.02 × 10−3 Innate immune response; inflammatory response; positive regulation of type I interferon-mediated signaling pathway; positive regulation of type I interferon production; toll-like receptor signaling pathway