Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator

Table 1 COMT amplicon description

Amplicon name	Human build 37	Length	CpG
Amplicon name	Position, Chr. 22	BP	Coverage
COMT_001	19928951	400	37
COMT_002	19938388	418	17
COMT_003	19938762	371	13
COMT_004*	19940043	226	8
COMT_005	19946527	438	20
COMT_006	19949994	392	16
COMT_007*	19955930	379	14
COMT_008	19949536	484	11
COMT_009*	19950497	405	11
COMT_010	19951020	277	14
COMT_011*	19951513	455	11
COMT_012*	19931875	379	17
COMT_013	19935171	394	14

COMT amplicons 001 – 013 are listed together with their human build NCBI 37/hg 19 bp location on chromosome 22. Amplicon size (in bp), together with the number of CpGs interrogated for methylation are provided. *amplicons were not differentially methylated, or could not be reliability amplified due to repetitive DNA sequence in the region (COMT_004, see Figure 1).

ISSN: 1755-8794