Skip to main content

Table 3 COMT methylation in healthy human subjects versus individual factors

From: Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator

CpG Units Age Sexa AUDIT score Ethnicityb SES COMTMetalleles
r (95% CI) p
001_1 -.099 (-.401, .390) .565 .071 (-.397, .357) .681 -.021 (-.461, .381) .905 -.124 (-.556, .247) .470 .039 (-.236, .262) .821 .003 (-.381, .474) .988
001_3.4 -.022 (-.241, .292) .901 -.051 (-.331, .313) .766 -.085 (-.411, .336) .612 -.187 (-.454, .216) .274 -.137 (-.546, .164) .425 -.084 (-.322, .331) .624
001_34 .037 (-.221, .355) .830 -.081 (-.352, .243) .639 -.206 (-.543, .110) .227 -.201 (-.568, .166) .239 -.331 (-.653, .044) .049* -.018 (-.290, .336) .919
001_avg -.029 (-.256, .265) .865 -.034 (-.348, .223) .845 -.169 (-.482, .158) .323 -.235 (-.520, .146) .168 -.232 (-.521, .065) .174 -.037 (-.358, .343) .830
002_1 -.051 (-.373, .284) .768 .058 (-.258, .415) .737 .038 (-.263, .386) .825 .195 (-.134, .528) .256 -.189 (-.479, .124) .269 .130 (-.214, .454) .451
002_5 .073 (-.382, .440) .673 .168 (-.161, .529) .326 .038 (-.270, .338) .826 -.066 (-.386, .311) .701 -.235 (-.542, .117) .168 .282 (-.090, .600) .096
002_10 .002 (-.348, .382) .991 .081 (-.222, .434) .638 -.044 (-.351, .278) .797 .145 (-.208, .498) 398 -.222 (-454, .046) .194 .257 (-.049, .514) .130
002_avg -.009 (-.336, .338) .960 .097 (-.195, .463) .574 .009 (-.307, .324) .959 .140 (-.208, .494) 415 -.230 (-.470, .092) .177 .227 (-.100, .495) .184
003_1 -.118 (-.461, .229) .479 -.199 (-.484, .137) .231 -.052 (-.334, .230) .758 .421 (.103, .696) .008** -.081 (-260, .412) .665 .138(-.182, .423) .408
003_3 -.154 (-.415, .131) .363 .165 (-.152, .467) .329 -.099 (-.379, .222) .561 -.278 (-.520, .008) .096 .074 (-.260, .412) .665 -.013 (-.376, .308) .940
003_6 .135 (-.128, .387) .433 -.188 (-.453, .120) .272 .151 (-.146, .443) .379 -.162 (-.396, .112) .344 -.223 (-.435, .046) .190 -.092 (-.450, .291) .593
003_avg .031 (-.301, .306) .853 -.107 (-.420, .182) .522 .061 (-.252, .339) .717 -.049 (-.390, .311) .769 -.187 (-.509, .209) .260 -.013 (-.359, .352) .937
005_2 -.239 (-.555, .214) .148 .028 (-.327, .356) .866 -.159 (-.434, .156) .341 -.209 (-.503, .184) .208 .041 (-.261, .366) .806 -.333 (-.596, -.063) .041*
005_3 -.065 (-.343, .273) .700 -.125 (-.422, .201) .454 -.116 ( -.391, .203) .489 -.159 (-.447, .176) .340 -.091 (-.358, .209) .587 -.193 (-.513, .128) .247
005_5 -.127 (-.416, .236) .446 .039 (-.283, .378) .815 -.068 (-.401, .262) .685 -.144 (-.438, .197) .388 -.136 (-.398, .202) .414 -.317 (-.592, -.047) .053
005_7 -.147 (-.451, .229) .380 -.120 (-.403, .216) .922 -.072 (-.354, .229) 668 -.176 (-.444, .184) .291 -.099 (-.400, .216) .553 .265 (-.547, .039) .107
005_8 -.103 (-.407, .280) .540 -.016 (-.349, .327) .922 -.120 (-.405, .192) .474 -.234 (-.523, .142) .157 -.074 (-.351, .264) .657 -.359 (-.601, -.072) .027*
005_9 -.058 (-.405, .381) .731 -.029 (-.342, .324) .863 -.207 (-.448, .117) .213 -.196 (-.511, .146) .239 .018 (-.329, .332) .914 -.077 (-.374, .160) .646
005_10 -.059 (-.381, .298) .723 -.064 (-.388, .276) .701 -.103 (-.416, .238) .539 -.276 (-.535, .084) .094 .120 (-.177, .431) .472 -.403 (-.632, -.108) .012*
005_17 .038 (-.230, .336) .819 -.193 (-.496, .172) .245 -.144 (-.418, .135) .389 -.290 (-.551, .030) .078 .086 (-.241, .413) .607 -.383 (-.613, -.137) .018*
005_18 -.022 (-.310, .327) .897 -.181 (-.471, .153) .284 -.203 (-.478, .131) .229 - .345 (-.623, -.026) .037* .007 (-.297, .305) .968 -.379 (-.585, -.123) .021*
005_avg -.098 (-.414, .299) .558 -.083 (-.398, .234) .621 -.161 (-.435, .152) .333 -.257 (-.542, .099) .119 -.017 (-.358, .336) .921 -.325 (-.588, -.049) .046*
006_3c -.031 (-.357, .241) .856 -.037 (-.364, .320) .823 -.056 (-.347, .256) .738 -.336 (-.644, .051) .039* .158 (-.200, .480) .342 .013 (-.333, .309) .937
006_4 -.027 (-.333, .259) .873 -.099 (-.412, .263) .554 -.094 (-.242, .318) .774 -.242 (-.529, .131) .143 .152 (-.166, .567) .363 -.093 (-.410, .225) .580
006_7 -.060 (-.365, .221) .722 .079 (-.241, .392) .638 .048 (-.242, .318) .774 -.179 (-.433, .165) .282 .122 (-.144, .361) .467 -.198 (-.514, .119) .232
006_8 -.078 (-.390, .236) .642 -.096 (-.399, .240) .566 -.043 (-.402, .311) .798 -.102 (-.508, .271) .542 .213 (-.100, .479) .200 -.932 (-.970, -.879) < .001***
006_9 -.052 (-.354, .264) .758 -.080 (-.399, .292) .635 -.047 (-.338, .278) .782 -.211 (-.489, .129) .204 .036 (-.243, .343) .829 -.306 (-.571, -.040) .061
006_10 .037 (-.248, .331) .825 -.065 (-.415, .258) .697 -.095 (-.392, .254) .570 -.201 (-.521, .162) .226 .127 (-.147, .405) .449 -.178 (-.471, .115) .285
006_12 -.046 (-.338, .311) .782 -.093 (-.410, .267) .579 -.046 (-.344, .300) .782 -.199 (-.467, .181) .231 .058 (-.263, .356) .731 -.295 (-.557, -.041) .072
006_13 -.077 (-.383, .255) .645 -.027 (-.354, .309) .874 .007 (-.315, .371) .968 -.112 (-.470, .267) .504 .072 (-.164, .339) .669 -.313 (-.590, -.021) .056
006_14.15 -.054 (-.359, .239) .746 -.109 (-.455, 236) .515 -.059 (-.381, .319) .723 -.188 (-.481, .175) .259 .120 (-.162, .407) .474 -.329 (-.579, -.063) .044*
006_16 -.050 (-.362, .278) .766 -.128 (-.450, .221) .445 -.019 (-.338, .308) .911 -.207 (-.494, .182) .212 .086 (-.222, .396) .609 -.337 (-.600, -.062) .039*
006_avg -.048 (-.350, .270) .776 -.065 (-.403, .266) .697 -.040 (-.348, .276) .813 -.212 (-.531, .161) .201 .120 (-.175, .395) .474 -.411 (-.638, -.163) .010*
008_3 -.109 (-.370, .195) .528 -.253 (-.557, .125) .136 -.033 (-.269, .221) .850 -.160 (-.482, .206) .351 .168 (-.194, .469) .326 .557 (.278, .738) < .001***
008_4 .199 (-.053, .411) .238 .056 (-.368, .275) .742 -.086 (-.350, .401) .613 -.203 (-.412, .097) .229 -.027 (-.247, .198) .875 .103 (-.484, .381) .543
008_6 .144 (-.175, .413) .394 .110 (-.240, .443) .516 .082 (-.210, .429) .631 -.189 (-.471, .151) .262 .007 (-.275, .322) .968 -.009 (-.340, .297) .956
008_10 .110 (-.169, .397) .516 .088 (-.256, .389) .606 .054 (-.300, .343) .751 -.205 (-.566, .186) .223 -.008 (-.347, .314) .965 -.196 (-.519, .101) .245
008_avg .078 (-.219, .352) .647 -.061 (-.375, .260) .718 -.011 (-.253, .293) .946 -.257 (-.578, .146) .125 .081 (-.197, .358) .632 .330 (-.035, .562) .046*
010_2 -.050 (-.390, .293) .765 .017 (-.351, .325) .919 -.170 (-.475, .154) .308 -.282 (-.595, .145) .086 .106 (-.228, .410) .527 -.228 (-.521, .043) .169
010_3.4 -.140 (-.41, .193) .401 -.021 (-.331, .301) .901 -.085 (-.411, .336) .612 -.202 (-.492, .196) .224 .094 (-.244, .385) .575 -.362 (-.605, -.073) .026*
010_6 -.154 (-.438, .207) .357 -.010 (-.352, .324) .954 -.146 (-.469, .173) .383 -.188 (-.506, .221) .259 .112 (-.223, .385) .502 -.317 (-.591, -.004) .053
010_8 -.159 (-.434, .166) .339 -.048 (-.381, .271) .775 -.194 (-.502, .171) .243 -.174 (-.494, .219) .295 .117 (-.229, .413) .482 -.336 (-.599, -.052) .039*
010_14d -.145 (-.414, .177) .386 .004 (-.373, .325) .980 -.168 (-.483, .180) .313 -.218 (-.501, .156) .189 .040 (-.291, .414) .814 .241 (-.142, .546) .145
010_ avg -.128 (-.432, .230) .444 -.015 (-.342, .296) .928 -.154 (-.495, .192) .356 -.220 (-.555, .182) .185 .110 (-.238, .395) .509 -.318 (-.587, -.031) .052
  1. Pearson partial correlation coefficients were calculated using a bootstrapping procedure based on percent methylation values for COMT CpG units within the top 40th percentile for differential methylation within the healthy human sample. Correlations in each column controlled for all other column variables. Results are based on n = 48 samples. AUDIT, Alcohol Use Disorders Identification Test; CI, confidence interval; SES, socioeconomic status. amale = 0, female = 1; bwhite = 1, non-white = 0 cNot within 40th percentile for differential methylation, but selected a priori based on [56]. dNot within 40th percentile for differential methylation, but selected a priori because CpG unit is located within the rs4680 SNP and present only in COMTVal allele [33]. *p < .05, **p < .01, ***p < .001, uncorrected for FWE, FDR corrected (p < .05).