Table 3 COMT methylation in healthy human subjects versus individual factors
CpG Units | Age | Sexa | AUDIT score | Ethnicityb | SES | COMTMetalleles |
|---|---|---|---|---|---|---|
r (95% CI) p | ||||||
001_1 | -.099 (-.401, .390) .565 | .071 (-.397, .357) .681 | -.021 (-.461, .381) .905 | -.124 (-.556, .247) .470 | .039 (-.236, .262) .821 | .003 (-.381, .474) .988 |
001_3.4 | -.022 (-.241, .292) .901 | -.051 (-.331, .313) .766 | -.085 (-.411, .336) .612 | -.187 (-.454, .216) .274 | -.137 (-.546, .164) .425 | -.084 (-.322, .331) .624 |
001_34 | .037 (-.221, .355) .830 | -.081 (-.352, .243) .639 | -.206 (-.543, .110) .227 | -.201 (-.568, .166) .239 | -.331 (-.653, .044) .049* | -.018 (-.290, .336) .919 |
001_avg | -.029 (-.256, .265) .865 | -.034 (-.348, .223) .845 | -.169 (-.482, .158) .323 | -.235 (-.520, .146) .168 | -.232 (-.521, .065) .174 | -.037 (-.358, .343) .830 |
002_1 | -.051 (-.373, .284) .768 | .058 (-.258, .415) .737 | .038 (-.263, .386) .825 | .195 (-.134, .528) .256 | -.189 (-.479, .124) .269 | .130 (-.214, .454) .451 |
002_5 | .073 (-.382, .440) .673 | .168 (-.161, .529) .326 | .038 (-.270, .338) .826 | -.066 (-.386, .311) .701 | -.235 (-.542, .117) .168 | .282 (-.090, .600) .096 |
002_10 | .002 (-.348, .382) .991 | .081 (-.222, .434) .638 | -.044 (-.351, .278) .797 | .145 (-.208, .498) 398 | -.222 (-454, .046) .194 | .257 (-.049, .514) .130 |
002_avg | -.009 (-.336, .338) .960 | .097 (-.195, .463) .574 | .009 (-.307, .324) .959 | .140 (-.208, .494) 415 | -.230 (-.470, .092) .177 | .227 (-.100, .495) .184 |
003_1 | -.118 (-.461, .229) .479 | -.199 (-.484, .137) .231 | -.052 (-.334, .230) .758 | .421 (.103, .696) .008** | -.081 (-260, .412) .665 | .138(-.182, .423) .408 |
003_3 | -.154 (-.415, .131) .363 | .165 (-.152, .467) .329 | -.099 (-.379, .222) .561 | -.278 (-.520, .008) .096 | .074 (-.260, .412) .665 | -.013 (-.376, .308) .940 |
003_6 | .135 (-.128, .387) .433 | -.188 (-.453, .120) .272 | .151 (-.146, .443) .379 | -.162 (-.396, .112) .344 | -.223 (-.435, .046) .190 | -.092 (-.450, .291) .593 |
003_avg | .031 (-.301, .306) .853 | -.107 (-.420, .182) .522 | .061 (-.252, .339) .717 | -.049 (-.390, .311) .769 | -.187 (-.509, .209) .260 | -.013 (-.359, .352) .937 |
005_2 | -.239 (-.555, .214) .148 | .028 (-.327, .356) .866 | -.159 (-.434, .156) .341 | -.209 (-.503, .184) .208 | .041 (-.261, .366) .806 | -.333 (-.596, -.063) .041* |
005_3 | -.065 (-.343, .273) .700 | -.125 (-.422, .201) .454 | -.116 ( -.391, .203) .489 | -.159 (-.447, .176) .340 | -.091 (-.358, .209) .587 | -.193 (-.513, .128) .247 |
005_5 | -.127 (-.416, .236) .446 | .039 (-.283, .378) .815 | -.068 (-.401, .262) .685 | -.144 (-.438, .197) .388 | -.136 (-.398, .202) .414 | -.317 (-.592, -.047) .053 |
005_7 | -.147 (-.451, .229) .380 | -.120 (-.403, .216) .922 | -.072 (-.354, .229) 668 | -.176 (-.444, .184) .291 | -.099 (-.400, .216) .553 | .265 (-.547, .039) .107 |
005_8 | -.103 (-.407, .280) .540 | -.016 (-.349, .327) .922 | -.120 (-.405, .192) .474 | -.234 (-.523, .142) .157 | -.074 (-.351, .264) .657 | -.359 (-.601, -.072) .027* |
005_9 | -.058 (-.405, .381) .731 | -.029 (-.342, .324) .863 | -.207 (-.448, .117) .213 | -.196 (-.511, .146) .239 | .018 (-.329, .332) .914 | -.077 (-.374, .160) .646 |
005_10 | -.059 (-.381, .298) .723 | -.064 (-.388, .276) .701 | -.103 (-.416, .238) .539 | -.276 (-.535, .084) .094 | .120 (-.177, .431) .472 | -.403 (-.632, -.108) .012* |
005_17 | .038 (-.230, .336) .819 | -.193 (-.496, .172) .245 | -.144 (-.418, .135) .389 | -.290 (-.551, .030) .078 | .086 (-.241, .413) .607 | -.383 (-.613, -.137) .018* |
005_18 | -.022 (-.310, .327) .897 | -.181 (-.471, .153) .284 | -.203 (-.478, .131) .229 | - .345 (-.623, -.026) .037* | .007 (-.297, .305) .968 | -.379 (-.585, -.123) .021* |
005_avg | -.098 (-.414, .299) .558 | -.083 (-.398, .234) .621 | -.161 (-.435, .152) .333 | -.257 (-.542, .099) .119 | -.017 (-.358, .336) .921 | -.325 (-.588, -.049) .046* |
006_3c | -.031 (-.357, .241) .856 | -.037 (-.364, .320) .823 | -.056 (-.347, .256) .738 | -.336 (-.644, .051) .039* | .158 (-.200, .480) .342 | .013 (-.333, .309) .937 |
006_4 | -.027 (-.333, .259) .873 | -.099 (-.412, .263) .554 | -.094 (-.242, .318) .774 | -.242 (-.529, .131) .143 | .152 (-.166, .567) .363 | -.093 (-.410, .225) .580 |
006_7 | -.060 (-.365, .221) .722 | .079 (-.241, .392) .638 | .048 (-.242, .318) .774 | -.179 (-.433, .165) .282 | .122 (-.144, .361) .467 | -.198 (-.514, .119) .232 |
006_8 | -.078 (-.390, .236) .642 | -.096 (-.399, .240) .566 | -.043 (-.402, .311) .798 | -.102 (-.508, .271) .542 | .213 (-.100, .479) .200 | -.932 (-.970, -.879) < .001*** |
006_9 | -.052 (-.354, .264) .758 | -.080 (-.399, .292) .635 | -.047 (-.338, .278) .782 | -.211 (-.489, .129) .204 | .036 (-.243, .343) .829 | -.306 (-.571, -.040) .061 |
006_10 | .037 (-.248, .331) .825 | -.065 (-.415, .258) .697 | -.095 (-.392, .254) .570 | -.201 (-.521, .162) .226 | .127 (-.147, .405) .449 | -.178 (-.471, .115) .285 |
006_12 | -.046 (-.338, .311) .782 | -.093 (-.410, .267) .579 | -.046 (-.344, .300) .782 | -.199 (-.467, .181) .231 | .058 (-.263, .356) .731 | -.295 (-.557, -.041) .072 |
006_13 | -.077 (-.383, .255) .645 | -.027 (-.354, .309) .874 | .007 (-.315, .371) .968 | -.112 (-.470, .267) .504 | .072 (-.164, .339) .669 | -.313 (-.590, -.021) .056 |
006_14.15 | -.054 (-.359, .239) .746 | -.109 (-.455, 236) .515 | -.059 (-.381, .319) .723 | -.188 (-.481, .175) .259 | .120 (-.162, .407) .474 | -.329 (-.579, -.063) .044* |
006_16 | -.050 (-.362, .278) .766 | -.128 (-.450, .221) .445 | -.019 (-.338, .308) .911 | -.207 (-.494, .182) .212 | .086 (-.222, .396) .609 | -.337 (-.600, -.062) .039* |
006_avg | -.048 (-.350, .270) .776 | -.065 (-.403, .266) .697 | -.040 (-.348, .276) .813 | -.212 (-.531, .161) .201 | .120 (-.175, .395) .474 | -.411 (-.638, -.163) .010* |
008_3 | -.109 (-.370, .195) .528 | -.253 (-.557, .125) .136 | -.033 (-.269, .221) .850 | -.160 (-.482, .206) .351 | .168 (-.194, .469) .326 | .557 (.278, .738) < .001*** |
008_4 | .199 (-.053, .411) .238 | .056 (-.368, .275) .742 | -.086 (-.350, .401) .613 | -.203 (-.412, .097) .229 | -.027 (-.247, .198) .875 | .103 (-.484, .381) .543 |
008_6 | .144 (-.175, .413) .394 | .110 (-.240, .443) .516 | .082 (-.210, .429) .631 | -.189 (-.471, .151) .262 | .007 (-.275, .322) .968 | -.009 (-.340, .297) .956 |
008_10 | .110 (-.169, .397) .516 | .088 (-.256, .389) .606 | .054 (-.300, .343) .751 | -.205 (-.566, .186) .223 | -.008 (-.347, .314) .965 | -.196 (-.519, .101) .245 |
008_avg | .078 (-.219, .352) .647 | -.061 (-.375, .260) .718 | -.011 (-.253, .293) .946 | -.257 (-.578, .146) .125 | .081 (-.197, .358) .632 | .330 (-.035, .562) .046* |
010_2 | -.050 (-.390, .293) .765 | .017 (-.351, .325) .919 | -.170 (-.475, .154) .308 | -.282 (-.595, .145) .086 | .106 (-.228, .410) .527 | -.228 (-.521, .043) .169 |
010_3.4 | -.140 (-.41, .193) .401 | -.021 (-.331, .301) .901 | -.085 (-.411, .336) .612 | -.202 (-.492, .196) .224 | .094 (-.244, .385) .575 | -.362 (-.605, -.073) .026* |
010_6 | -.154 (-.438, .207) .357 | -.010 (-.352, .324) .954 | -.146 (-.469, .173) .383 | -.188 (-.506, .221) .259 | .112 (-.223, .385) .502 | -.317 (-.591, -.004) .053 |
010_8 | -.159 (-.434, .166) .339 | -.048 (-.381, .271) .775 | -.194 (-.502, .171) .243 | -.174 (-.494, .219) .295 | .117 (-.229, .413) .482 | -.336 (-.599, -.052) .039* |
010_14d | -.145 (-.414, .177) .386 | .004 (-.373, .325) .980 | -.168 (-.483, .180) .313 | -.218 (-.501, .156) .189 | .040 (-.291, .414) .814 | .241 (-.142, .546) .145 |
010_ avg | -.128 (-.432, .230) .444 | -.015 (-.342, .296) .928 | -.154 (-.495, .192) .356 | -.220 (-.555, .182) .185 | .110 (-.238, .395) .509 | -.318 (-.587, -.031) .052 |