Table 1 Number of samples assigned exclusively and significantly (p < 0.05 and p < 0.25, dependent correlations by Steiger[38]) to one of the four PCa subtypes, compared to the number of samples assigned when the four categories are combined into two categories with bad and good prognosis

PCa

0.05

10

0

0

1

37

10

0.25

22

3

2

11

52

21

Normal

0.05

0

0

2

7

0

31

0.25

0

0

4

17

0

35

B) Signatures subtracted for the average normal signature

p-value threshold

BP-E/P/Pr

BP-ERG

GP1

GP2

Bad prognosis

Good prognosis

PCa

0.05

9

1

0

1

53

4

0.25

23

5

0

4

73

7

Normal

0.05

0

0

0

6

3

12

0.25

4

0

2

13

7

19