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Table 1 Number of samples assigned exclusively and significantly (p < 0.05 and p < 0.25, dependent correlations by Steiger[38]) to one of the four PCa subtypes, compared to the number of samples assigned when the four categories are combined into two categories with bad and good prognosis

From: Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer

A) Original signature
  p-value threshold BP-E/P/Pr BP-ERG GP1 GP2 Bad prognosis Good prognosis
PCa 0.05 10 0 0 1 37 10
  0.25 22 3 2 11 52 21
Normal 0.05 0 0 2 7 0 31
  0.25 0 0 4 17 0 35
B) Signatures subtracted for the average normal signature
  p-value threshold BP-E/P/Pr BP-ERG GP1 GP2 Bad prognosis Good prognosis
PCa 0.05 9 1 0 1 53 4
  0.25 23 5 0 4 73 7
Normal 0.05 0 0 0 6 3 12
  0.25 4 0 2 13 7 19
  1. While only few samples could be assigned exclusively to one of the four subtypes, a substantial number of samples could be assigned to one of the two combined categories of good and bad prognosis.